Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages (Q33478364)

27 July 2017

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages (English)

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27 July 2017

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Ivet Bahar

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John S. Lazo

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object named as

John S Lazo

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27 July 2017

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Andreas Vogt

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27 July 2017

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Thomas E Smithgall

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27 July 2017

Gabriela Molina

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27 July 2017

Ahmet Bakan

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27 July 2017

Weixiang Dai

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27 July 2017

Pierre Queiroz de Oliveira

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27 July 2017

Wade Znosko

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27 July 2017

Billy W Day

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27 July 2017

Michael Tsang

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27 July 2017

Michael Tsang

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27 July 2017

5 July 2009

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27 July 2017

Nature Chemical Biology

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27 July 2017

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27 July 2017

680-687

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27 July 2017

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https://scigraph.springernature.com/pub.10.1038/nchembio.190

27 July 2017

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Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening

21 June 2018

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DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility

21 June 2018

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Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification

21 June 2018

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Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart

21 June 2018

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Wound repair and regeneration

21 June 2018

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Structural genomics of protein phosphatases

21 June 2018

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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

21 June 2018

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Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation

21 June 2018

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Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

21 June 2018

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Generation of FGF reporter transgenic zebrafish and their utility in chemical screens.

21 June 2018

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Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases

21 June 2018

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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

21 June 2018

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Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development

21 June 2018

1 reference

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Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase

21 June 2018

1 reference

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Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase

21 June 2018

1 reference

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Functions and regulations of fibroblast growth factor signaling during embryonic development

21 June 2018

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Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets

21 June 2018

1 reference

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Mechanisms underlying differential responses to FGF signaling

21 June 2018

1 reference

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Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease

21 June 2018

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Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants

21 June 2018

1 reference

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Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5

21 June 2018

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In vivo drug discovery in the zebrafish

21 June 2018

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A role for MKP3 in axial patterning of the zebrafish embryo

21 June 2018

1 reference

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Promotion and attenuation of FGF signaling through the Ras-MAPK pathway

21 June 2018

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FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Identification of Sef, a novel modulator of FGF signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Cardiac patterning and morphogenesis in zebrafish

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

A gene expression screen in zebrafish embryogenesis.

21 June 2018

1 reference

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Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1

21 June 2018

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Anisotropy of fluctuation dynamics of proteins with an elastic network model

21 June 2018

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Small molecule developmental screens reveal the logic and timing of vertebrate development

21 June 2018

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Genetics of heart development.

21 June 2018

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Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation

21 June 2018

1 reference

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Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases

21 June 2018

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The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Development and validation of a genetic algorithm for flexible docking

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Vessel and blood specification override cardiac potential in anterior mesoderm

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Changes in Sef levels influence auditory brainstem development and function.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Organization of cardiac chamber progenitors in the zebrafish blastula

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771339

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19578332

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.190

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.190

1 reference

27 July 2017

1 reference

27 July 2017

1 reference