SUMO-regulated mitochondrial function in Parkinson's disease (Q38757045)

6 September 2017

SUMO-regulated mitochondrial function in Parkinson's disease (English)

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6 September 2017

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Ana Cristina Guerra de Souza

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1

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6 September 2017

Rui Daniel Prediger

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2

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6 September 2017

Helena Cimarosti

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3

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6 September 2017

language of work or name

English

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publication date

2 March 2016

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Journal of Neurochemistry

6 September 2017

14

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based on heuristic

inferred from page(s)

published in

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6 September 2017

137

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6 September 2017

673-686

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6 September 2017

5

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A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

6 September 2017

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Extent of inhibition of α-synuclein aggregation in vitro by SUMOylation is conjugation site- and SUMO isoform-selective.

21 January 2018

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Chaperone-mediated autophagy markers in Parkinson disease brains

21 January 2018

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A further update on the role of excitotoxicity in the pathogenesis of Parkinson's disease

21 January 2018

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21 January 2018

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SUMO wrestling with Drp1 at mitochondria

21 January 2018

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DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

21 January 2018

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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

21 January 2018

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Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

21 January 2018

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Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

21 January 2018

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Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

21 January 2018

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The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases

21 January 2018

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Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons

21 January 2018

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Oxidative stress and Parkinson's disease

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

21 January 2018

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Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control

21 January 2018

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Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance.

21 January 2018

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SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α.

21 January 2018

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α-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions.

21 January 2018

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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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Early Parkinson's disease and non-motor issues

21 January 2018

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Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

21 January 2018

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Non-motor symptoms of Parkinson's disease: diagnosis and management

21 January 2018

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

21 January 2018

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Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

21 January 2018

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Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.

21 January 2018

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Functions and dysfunctions of mitochondrial dynamics

21 January 2018

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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

21 January 2018

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Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

21 January 2018

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The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

21 January 2018

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Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease

21 January 2018

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SUMO protein modification.

21 January 2018

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Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

21 January 2018

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SUMO and Parkinson's disease

21 January 2018

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Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

21 January 2018

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SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

21 January 2018

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Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration

21 January 2018

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PINK1 protein in normal human brain and Parkinson's disease

21 January 2018

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The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

21 January 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

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Concepts in sumoylation: a decade on

21 January 2018

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Models of α-synuclein aggregation in Parkinson's disease

21 January 2018

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Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates

21 January 2018

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A large kindred with autosomal dominant Parkinson's disease

21 January 2018

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6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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α-Synuclein is localized to mitochondria-associated ER membranes

21 January 2018

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A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

21 January 2018

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SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.

21 January 2018

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Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease.

21 January 2018

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Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission.

21 January 2018

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SUMO: a history of modification

21 January 2018

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DJ-1 binds to mitochondrial complex I and maintains its activity

21 January 2018

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Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction

21 January 2018

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DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly

21 January 2018

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Transcriptional control of mitochondrial biogenesis and function

21 January 2018

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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

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Mitochondrial dynamics in neurodegeneration

21 January 2018

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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

21 January 2018

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Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

21 January 2018

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

21 January 2018

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Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Mitochondrial fragmentation in neurodegeneration

21 January 2018

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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Sumoylation in neurodegenerative diseases

21 January 2018

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Sumoylation inhibits alpha-synuclein aggregation and toxicity.

21 January 2018

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Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

21 January 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism

21 January 2018

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

21 January 2018

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Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

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Receptor trafficking and the regulation of synaptic plasticity by SUMO.

21 January 2018

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Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

21 January 2018

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Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

21 January 2018

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Comparison of SUMO fusion technology with traditional gene fusion systems: enhanced expression and solubility with SUMO.

21 January 2018

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

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Crosstalk between mitochondrial (dys)function and mitochondrial abundance

21 January 2018

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Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

21 January 2018

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Parkin: a multifaceted ubiquitin ligase.

21 January 2018

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Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

21 January 2018

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Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

21 January 2018

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

21 January 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

21 January 2018

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Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation

21 January 2018

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Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1.

21 January 2018

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The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering.

21 January 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

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SUMO fusion technology for enhanced protein production in prokaryotic and eukaryotic expression systems

21 January 2018

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Mitochondrial association of alpha-synuclein causes oxidative stress

21 January 2018

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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease

21 January 2018

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Non-motor symptoms in Parkinson's disease

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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The PINK1/Parkin pathway regulates mitochondrial morphology

21 January 2018

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The prevalence of Parkinson's disease: a systematic review and meta-analysis

21 January 2018

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Oxidative stress promotes uptake, accumulation, and oligomerization of extracellular α-synuclein in oligodendrocytes

21 January 2018

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Gene-environment interactions in Parkinson's disease

21 January 2018

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SUMOylation attenuates the function of PGC-1alpha

21 January 2018

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When does Parkinson disease start?

21 January 2018

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Complex I: inhibitors, inhibition and neurodegeneration

21 January 2018

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Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

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Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

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Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.

21 January 2018

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Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update

21 January 2018

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Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions

21 January 2018

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Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

21 January 2018

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Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

21 January 2018

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Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease

21 January 2018

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Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia

21 January 2018

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Alpha-synuclein in Lewy bodies

21 January 2018

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

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DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

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Rotenone, paraquat, and Parkinson's disease

21 January 2018

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

21 January 2018

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PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

21 January 2018

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Functional modulation of parkin through physical interaction with SUMO-1.

21 January 2018

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PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

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Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity

21 January 2018

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New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

21 January 2018

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Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair

21 January 2018

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PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

21 January 2018

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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

21 January 2018

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PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons

21 January 2018

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Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

21 January 2018

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Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death

21 January 2018

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Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease.

21 January 2018

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Targets and consequences of protein SUMOylation in neurons.

21 January 2018

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Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease

21 January 2018

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SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases

21 January 2018

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

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The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

21 January 2018

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Paralysis agitans of early onset with marked diurnal fluctuation of symptoms

21 January 2018

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

21 January 2018

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Mitochondrial fission, fusion, and stress

21 January 2018

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The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

21 January 2018

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Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

21 January 2018

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DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection.

21 January 2018

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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

21 January 2018

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Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation

21 January 2018

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DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor

21 January 2018

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After the banquet: mitochondrial biogenesis, mitophagy, and cell survival

21 January 2018

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All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-.

21 January 2018

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Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis

21 January 2018

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The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease

21 January 2018

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Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation

21 January 2018

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The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

21 January 2018

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Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.13599

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6 September 2017

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