Concepts in sumoylation: a decade on (Q28257220)

Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C

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cites work

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UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins

31 March 2020

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A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

31 March 2020

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

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Something about SUMO inhibits transcription

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Sumoylation in neurons: nuclear and synaptic roles?

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Protein modification by SUMO

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SUMO: ligases, isopeptidases and nuclear pores

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Viruses and sumoylation: recent highlights

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SUMO and transcriptional regulation

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Nuclear and unclear functions of SUMO

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Structure determination of the small ubiquitin-related modifier SUMO-1

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Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

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Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes

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SUMO--nonclassical ubiquitin

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Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3

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A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers

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Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics

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A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation

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The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

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Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

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Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential

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The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice

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Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation

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SUMO1 haploinsufficiency leads to cleft lip and palate

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Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1

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In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2

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Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex

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Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p

31 March 2020

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Ubch9 conjugates SUMO but not ubiquitin

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Modification of Ran GTPase-activating Protein by the Small Ubiquitin-related Modifier SUMO-1 Requires Ubc9, an E2-type Ubiquitin-conjugating Enzyme Homologue

31 March 2020

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Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2

31 March 2020

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SP-RING for SUMO: new functions bloom for a ubiquitin-like protein

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PIAS proteins and transcriptional regulation--more than just SUMO E3 ligases?

31 March 2020

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An E3-like factor that promotes SUMO conjugation to the yeast septins

31 March 2020

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Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates

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Involvement of PIAS1 in the sumoylation of tumor suppressor p53

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Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

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PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription

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Transcription factor Sp3 is silenced through SUMO modification by PIAS1

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PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1

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PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

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PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

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Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage

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Human MMS21/NSE2 is a SUMO ligase required for DNA repair

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The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

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SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae

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The nucleoporin RanBP2 has SUMO1 E3 ligase activity

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The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

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Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex

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Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

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The polycomb protein Pc2 is a SUMO E3

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Multiple activities contribute to Pc2 E3 function

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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications

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Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors

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Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

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An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity

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Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

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The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast

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SUSP1 antagonizes formation of highly SUMO2/3-conjugated species

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The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein

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A new protease required for cell-cycle progression in yeast

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The SUMO-specific protease SENP5 is required for cell division

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Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.

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The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity

31 March 2020

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Association of the human SUMO-1 protease SENP2 with the nuclear pore

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Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.

31 March 2020

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A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase

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The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

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Differential regulation of sentrinized proteins by a novel sentrin-specific protease

31 March 2020

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Characterization of the Localization and Proteolytic Activity of the SUMO-specific Protease, SENP1

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A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs

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Modification in reverse: the SUMO proteases

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Molecular Characterization of the SUMO-1 Modification of RanGAP1 and Its Role in Nuclear Envelope Association

31 March 2020

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SUMO-1 Modification and Its Role in Targeting the Ran GTPase-activating Protein, RanGAP1, to the Nuclear Pore Complex

31 March 2020

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Identification of Three Major Sentrinization Sites in PML

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The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers

31 March 2020

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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

31 March 2020

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c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

31 March 2020

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Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence

31 March 2020

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SUMO modification of the ubiquitin-conjugating enzyme E2-25K

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PDSM, a motif for phosphorylation-dependent SUMO modification

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Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1

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An extended consensus motif enhances the specificity of substrate modification by SUMO

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

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p300 Transcriptional Repression Is Mediated by SUMO Modification

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Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

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ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation

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Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.

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Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1

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Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

31 March 2020

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Crystal structure of thymine DNA glycosylase conjugated to SUMO-1

31 March 2020

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Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif

31 March 2020

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Identification of a SUMO-binding motif that recognizes SUMO-modified proteins

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Specification of SUMO1- and SUMO2-interacting motifs

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Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae

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Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation

31 March 2020

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The mechanisms of PML-nuclear body formation

31 March 2020

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Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors

31 March 2020

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SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx

31 March 2020

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SUMO-targeted ubiquitin ligases in genome stability.

31 March 2020

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Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins

31 March 2020

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Ubiquitin-dependent proteolytic control of SUMO conjugates

31 March 2020

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The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation

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Ubiquitin-binding domains

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A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties.

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SUMO promotes HDAC-mediated transcriptional repression

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Negative modulation of androgen receptor transcriptional activity by Daxx

31 March 2020

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SUMO: a history of modification

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Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation

31 March 2020

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Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53

31 March 2020

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SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization

31 March 2020

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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

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Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest

31 March 2020

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PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.

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Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

31 March 2020

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A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation

31 March 2020

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Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins

31 March 2020

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Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells

31 March 2020

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The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress.

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Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

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A mechanism for inhibiting the SUMO pathway

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Targeting SUMO E1 to Ubiquitin Ligases

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Role of desumoylation in the development of prostate cancer

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A role for Ubc9 in tumorigenesis

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Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission

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Regulation of protein tyrosine phosphatase 1B by sumoylation

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Sumoylation silences the plasma membrane leak K+ channel K2P1.

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Does sumoylation control K2P1/TWIK1 background K+ channels?

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SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.

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Cloning and Expression of a Novel K+ Channel Regulatory Protein, KChAP

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Pias1 interaction and sumoylation of metabotropic glutamate receptor 8

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SUMOylation regulates kainate-receptor-mediated synaptic transmission

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SUMO on the road to neurodegeneration

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