Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses (Q38587949)

4 September 2017

Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses (English)

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4 September 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26376455%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1

Anna Wilkaniec

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26376455%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

3

Agata Adamczyk

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2 June 2020

language of work or name

English

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publication date

16 September 2015

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Journal of Neurochemistry

4 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26376455%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

136

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2 June 2020

issue

2

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2 June 2020

page(s)

222-233

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Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels.

2 June 2020

cites work

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Alpha-synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide.

21 January 2018

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Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on alpha-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain.

21 January 2018

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

21 January 2018

1 reference

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death.

21 January 2018

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A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons

21 January 2018

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Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

21 January 2018

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Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease

21 January 2018

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Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease.

21 January 2018

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Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

21 January 2018

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Inhibition of amyloid-β plaque formation by α-synuclein.

21 January 2018

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Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

21 January 2018

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Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons

21 January 2018

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c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

21 January 2018

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Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases.

21 January 2018

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Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

21 January 2018

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Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway

21 January 2018

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Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2.

21 January 2018

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CDK5 activator protein p25 preferentially binds and activates GSK3β

21 January 2018

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5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.

21 January 2018

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Transmission and spreading of tauopathy in transgenic mouse brain

21 January 2018

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Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease.

21 January 2018

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p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

21 January 2018

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Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells.

21 January 2018

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Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro.

21 January 2018

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The role of parkin in familial and sporadic Parkinson's disease

21 January 2018

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Parkin plays a role in sporadic Parkinson's disease

21 January 2018

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Lysosomal impairment in Parkinson's disease

21 January 2018

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Akt and CHIP coregulate tau degradation through coordinated interactions

21 January 2018

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The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells

21 January 2018

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Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models

21 January 2018

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

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Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator

21 January 2018

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Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease

21 January 2018

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Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.

21 January 2018

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A role for p53 in the beta-amyloid-mediated regulation of the lysosomal system

21 January 2018

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Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells

21 January 2018

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Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem

21 January 2018

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Phosphorylation of prion protein at serine 43 induces prion protein conformational change

21 January 2018

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Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease.

21 January 2018

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Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

21 January 2018

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p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

21 January 2018

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Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

21 January 2018

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Extracellular tau is toxic to neuronal cells.

21 January 2018

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Calpain inhibition prevents amyloid-beta-induced neurodegeneration and associated behavioral dysfunction in rats

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

21 January 2018

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Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

21 January 2018

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Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5

21 January 2018

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The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer's disease

21 January 2018

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alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

21 January 2018

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Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein

21 January 2018

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Making a neuron: Cdk5 in embryonic and adult neurogenesis.

21 January 2018

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Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

21 January 2018

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

21 January 2018

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Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease

21 January 2018

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Neurotoxicity of β-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis

21 January 2018

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Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β

21 January 2018

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alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.

21 January 2018

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A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5).

21 January 2018

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CDK5 serves as a major control point in neurotransmitter release.

21 January 2018

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SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP(+) and rotenone

21 January 2018

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Soluble Aβ oligomer production and toxicity

21 January 2018

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Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

21 January 2018

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Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

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Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

21 January 2018

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

21 January 2018

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Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

21 January 2018

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Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.

21 January 2018

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Epigenetic modulation of Cdk5 contributes to memory deficiency induced by amyloid fibrils.

21 January 2018

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Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

21 January 2018

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Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides.

21 January 2018

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Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain

21 January 2018

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Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons

21 January 2018

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Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.

21 January 2018

1 reference

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

21 January 2018

1 reference

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice

21 January 2018

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Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons

21 January 2018

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A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

21 January 2018

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21 January 2018

The many faces of tau

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p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease.

21 January 2018

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Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

21 January 2018

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Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo

21 January 2018

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Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide

21 January 2018

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The importance of tau phosphorylation for neurodegenerative diseases

21 January 2018

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Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking.

21 January 2018

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p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

21 January 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

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Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3

21 January 2018

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No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

21 January 2018

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Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

21 January 2018

1 reference

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

21 January 2018

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Memory enhancement by targeting Cdk5 regulation of NR2B.

21 January 2018

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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide

21 January 2018

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S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease

21 January 2018

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Cortical interneurons require p35/Cdk5 for their migration and laminar organization

21 January 2018

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Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

21 January 2018

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Tau, prions and Aβ: the triad of neurodegeneration

21 January 2018

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Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

21 January 2018

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CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton

21 January 2018

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Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease

21 January 2018

1 reference

The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models

21 January 2018

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Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors

21 January 2018

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Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

21 January 2018

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A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

21 January 2018

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 January 2018

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Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

21 January 2018

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

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Nuclear tau, a key player in neuronal DNA protection

21 January 2018

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Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment.

21 January 2018

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Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease

21 January 2018

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Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease

21 January 2018

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Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

21 January 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

21 January 2018

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A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

21 January 2018

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

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Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution.

21 January 2018

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Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.

21 January 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

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p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions

21 January 2018

1 reference

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

21 January 2018

1 reference

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 January 2018

1 reference

Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration

21 January 2018

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Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

21 January 2018

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D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

21 January 2018

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Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

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Cdk5 phosphorylates p53 and regulates its activity

21 January 2018

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Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

21 January 2018

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Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors.

21 January 2018

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Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival

21 January 2018

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A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation

21 January 2018

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Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

21 January 2018

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Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator

21 January 2018

1 reference

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.13365

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26376455%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

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