Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. (Q35006021)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

1 reference

C Patrick

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

A Adame

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

E Rockenstein

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

publication date

10 February 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

published in

Cell Death and Disease

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

e120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

24 January 2020

NeuronJ

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3101702/fullTextXML

24 May 2022

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3101702/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Making a neuron: Cdk5 in embryonic and adult neurogenesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cdk5 is essential for adult hippocampal neurogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Failure of neuronal maturation in Alzheimer disease dentate gyrus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Staying connected: synapses in Alzheimer disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Increased hippocampal neurogenesis in Alzheimer's disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Neurotoxicity induces cleavage of p35 to p25 by calpain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

The adult rat hippocampus contains primordial neural stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Generation and culturing of precursor cells and neuroblasts from embryonic and adult central nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101702

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Human Wild-Type α-Synuclein Impairs Neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2011.2

Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21368891

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2011.2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368891%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

21368891

1 reference