Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro. (Q43447647)

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7 March 2020

title

Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro (English)

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7 March 2020

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1

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Magdalena Gąssowska-Dobrowolska

7 March 2020

series ordinal

2

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7 March 2020

Magdalena Cieślik

series ordinal

4

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7 March 2020

3

Anna Wilkaniec

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7 March 2020

5

Agata Adamczyk

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7 March 2020

language of work or name

English

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publication date

14 August 2013

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7 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23954626%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

volume

587

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7 March 2020

issue

18

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7 March 2020

page(s)

3135-3141

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Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels.

7 March 2020

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Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

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The role of α-synuclein in neurotransmission and synaptic plasticity

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Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

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Cyclin-dependent protein kinase 5 activity increases in rat brain following ischemia

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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.

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A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5).

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Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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Alpha-synuclein: from secretion to dysfunction and death

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Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

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Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn.

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An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

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Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

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Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

21 January 2018

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A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 January 2018

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Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies

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Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

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Cdk5 phosphorylates p53 and regulates its activity

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