Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration (Q28140796)

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M Nikolic

3

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S de la Monte

4

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P Dikkes

5

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L H Tsai

A family of human cdc2-related protein kinases

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publication date

9 December 1999

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language of work or name

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402

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issue

6762

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page(s)

615-22

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cites work

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A brain-specific activator of cyclin-dependent kinase 5.

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Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

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Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.

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Callosal axon guidance defects in p35(-/-) mice

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A novel disruption of cortical development inp35?/? mice distinct fromreeler

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

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7 January 2021

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

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Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18

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Tau in Alzheimer's disease

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Tau protein pathology in neurodegenerative diseases

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Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain

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Identification of functional domains in the neuronal Cdk5 activator protein

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7 January 2021

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

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7 January 2021

The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning

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7 January 2021

p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway

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7 January 2021

Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.

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Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

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Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells

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7 January 2021

Phosphorylation by Neuronal cdc2-like Protein Kinase Promotes Dimerization of Tau Protein in Vitro

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7 January 2021

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

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7 January 2021

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

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7 January 2021

Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)

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7 January 2021

Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35

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7 January 2021

Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5.

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7 January 2021

Tau domains, phosphorylation, and interactions with microtubules.

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7 January 2021

Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain.

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7 January 2021

Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death

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7 January 2021

Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra

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7 January 2021

Expression of cell cycle-related genes during neuronal apoptosis: is there a distinct pattern?

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7 January 2021

Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling

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7 January 2021

Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions

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7 January 2021

Regulation of Munc-18/Syntaxin 1A Interaction by Cyclin-dependent Kinase 5 in Nerve Endings

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7 January 2021

The distribution of tau in the mammalian central nervous system

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7 January 2021

A neuronal antigen in the brains of Alzheimer patients

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7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

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7 January 2021

Integrated evaluation of central nervous system lesions: stains for neurons, astrocytes, and microglia reveal the spatial and temporal features of MK-801-induced neuronal necrosis in the rat cerebral cortex

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7 January 2021

Abnormally phosphorylated tau in SY5Y human neuroblastoma cells

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7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021