Targeting the unfolded protein response for disease intervention (Q38545670)

4 September 2017

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title

Targeting the unfolded protein response for disease intervention (English)

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4 September 2017

Alexis Rivas

1

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4 September 2017

René Luis Vidal

series ordinal

2

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4 September 2017

Claudio Hetz

series ordinal

3

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4 September 2017

language of work or name

English

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publication date

13 July 2015

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Expert Opinion on Therapeutic Targets

4 September 2017

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4 September 2017

19

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4 September 2017

1203-1218

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4 September 2017

9

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Protein quality control in the early secretory pathway

4 September 2017

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Autophagy is activated for cell survival after endoplasmic reticulum stress

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

When ER stress reaches a dead end

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The unfolded protein response in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

A transgenic mouse model for monitoring endoplasmic reticulum stress

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Perk is essential for translational regulation and cell survival during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Unfolding the role of protein misfolding in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Targeting autophagy in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Identification of a novel endoplasmic reticulum stress response element regulated by XBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Addicted to secrete - novel concepts and targets in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Unfolded protein response in cancer: the physician's perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The role of endoplasmic reticulum stress in human pathology

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Targeting endoplasmic reticulum stress in metabolic disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Pharmacological brake-release of mRNA translation enhances cognitive memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Targeting the unfolded protein response in disease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Druggable sensors of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

A molecular chaperone inducer protects neurons from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Hsp90: a novel target for the disruption of multiple signaling cascades

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Development of Radicicol Analogues

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Development of a Grp94 inhibitor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The potential of protein disulfide isomerase as a therapeutic drug target

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Protein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applications

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

InterfERing with endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Sodium 4-phenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Sensitization to docetaxel in prostate cancer cells by green tea and quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Autophagy fights disease through cellular self-digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Fighting neurodegeneration with rapamycin: mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

α-Tocopherol quinone inhibits β-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Green tea composition, consumption, and polyphenol chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

Extra virgin olive oil intake delays the development of amyotrophic lateral sclerosis associated with reduced reticulum stress and autophagy in muscle of SOD1G93A mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1053869

10.1517/14728222.2015.1053869

21 January 2018

Identifiers

DOI

1 reference

4 September 2017

1 reference