XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy (Q24655821)

9

object named as

Robert H Brown

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Laurie Glimcher

10

object named as

Laurie H Glimcher

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author name string

Claudio Hetz

1

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Peter Thielen

2

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Soledad Matus

3

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Melissa Nassif

4

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Felipe Court

5

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Roberta Kiffin

6

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Gabriela Martinez

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

7

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language of work or name

English

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publication date

1 October 2009

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published in

Genes & Development

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volume

23

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page(s)

2294-306

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issue

19

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

7 April 2017

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Misfolded proteins partition between two distinct quality control compartments

7 April 2017

1 reference

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The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD

7 April 2017

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Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

7 April 2017

1 reference

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

7 April 2017

1 reference

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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

7 April 2017

1 reference

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Plasma cell differentiation requires the transcription factor XBP-1

7 April 2017

1 reference

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Autophagy fights disease through cellular self-digestion

7 April 2017

1 reference

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Autophagy in the Pathogenesis of Disease

7 April 2017

1 reference

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Signal integration in the endoplasmic reticulum unfolded protein response

7 April 2017

1 reference

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Loss of autophagy in the central nervous system causes neurodegeneration in mice

7 April 2017

1 reference

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Regulation of hepatic lipogenesis by the transcription factor XBP1

7 April 2017

1 reference

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Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

7 April 2017

1 reference

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

7 April 2017

1 reference

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The roles of intracellular protein-degradation pathways in neurodegeneration

7 April 2017

1 reference

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

ALS: a disease of motor neurons and their nonneuronal neighbors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

VAPB interacts with and modulates the activity of ATF6.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Fine structure of the autophagosome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Closed head injury induces upregulation of Beclin 1 at the cortical site of injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758741

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

28 November 2018

1 reference

12 December 2020

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice

1 reference

12 December 2020

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

1 reference

12 December 2020

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1830709

1 reference

release_j5l6j6bainbo5khf4rqesnau3u

1741565

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/j5l6j6bainbo5khf4rqesnau3u

24 November 2022

mapped directly with Wikidata item

1741565

1 reference

1 reference

1 reference