Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases (Q38322767)

2 September 2017

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title

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases (English)

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2 September 2017

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Yu Tang

1

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PubMed ID

25598354

2 September 2017

Weidong Le

series ordinal

2

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2 September 2017

20 January 2015

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2 September 2017

Molecular Neurobiology

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2 September 2017

53

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2 September 2017

1181-1194

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2 September 2017

2

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https://scigraph.springernature.com/pub.10.1007/s12035-014-9070-5

2 September 2017

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Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.

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Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

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Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

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Assessing activation states in microglia

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Heterogeneity of microglial activation in the innate immune response in the brain

21 January 2018

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(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury

21 January 2018

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Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.

21 January 2018

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TGFβ signalling plays an important role in IL4-induced alternative activation of microglia

21 January 2018

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Neuroprotective role of microglia expressing interleukin-4.

21 January 2018

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TGFbeta1 regulates the inflammatory response during chronic neurodegeneration.

21 January 2018

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Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo

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Macrophage deactivation by interleukin 10

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The macrophage scavenger receptor CD163.

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Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

21 January 2018

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Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.

21 January 2018

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Alternative activation of macrophages

21 January 2018

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Recent advances in arginine metabolism

21 January 2018

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Regulation of immune responses by L-arginine metabolism

21 January 2018

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The role of extracellular matrix in CNS regeneration

21 January 2018

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Proline and hydroxyproline metabolism: implications for animal and human nutrition

21 January 2018

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Effect of 3-hydroxyproline residues on collagen stability

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Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications

21 January 2018

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Interactions of polyamines with ion channels

21 January 2018

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Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease

21 January 2018

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Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

21 January 2018

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FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family

21 January 2018

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Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin.

21 January 2018

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The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation

21 January 2018

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The mannose receptor: linking homeostasis and immunity through sugar recognition

21 January 2018

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The mannose receptor is a pattern recognition receptor involved in host defense

21 January 2018

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Mannose receptor-mediated regulation of serum glycoprotein homeostasis

21 January 2018

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Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program

21 January 2018

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C-type lectins and phagocytosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

21 January 2018

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M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway

21 January 2018

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Parkinson's disease: mechanisms and models

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Nitrated alpha-synuclein and microglial neuroregulatory activities

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Alpha-synuclein expression modulates microglial activation phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Rho kinase inhibitor fasudil regulates microglia polarization and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Pathways towards and away from Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Misfolded truncated protein τ induces innate immune response via MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Regulation of tau pathology by the microglial fractalkine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

ALS: a disease of motor neurons and their nonneuronal neighbors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglia in ALS: the good, the bad, and the resting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Redox modifier genes in amyotrophic lateral sclerosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Minocycline selectively inhibits M1 polarization of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Microglia display modest phagocytic capacity for extracellular tau oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

The changing phenotype of microglia from homeostasis to disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Immune activation in brain aging and neurodegeneration: too much or too little?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Aging enhances classical activation but mitigates alternative activation in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9070-5

Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia

21 January 2018

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12 December 2020

Genetics of Parkinson's disease

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12 December 2020

Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia

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12 December 2020

Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease

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12 December 2020

Interleukin-10, interleukin-4, and transforming growth factor-beta differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells

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12 December 2020

Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease.

1 reference

12 December 2020

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

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12 December 2020

Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase

1 reference

12 December 2020

Gene-expression profile of the ageing brain in mice

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12 December 2020

Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.

1 reference

12 December 2020

Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia

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12 December 2020

Transient expression of Ym1, a heparin-binding lectin, during developmental hematopoiesis and inflammation.

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12 December 2020

Tau oligomers and fibrils induce activation of microglial cells

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12 December 2020

Increased interleukin-6 expression by microglia from brain of aged mice.

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12 December 2020

Induction of Ym1/2 in mouse bone marrow-derived mast cells by IL-4 and identification of Ym1/2 in connective tissue type-like mast cells derived from bone marrow cells cultured with IL-4 and stem cell factor

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12 December 2020

Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli

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12 December 2020

Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

1 reference

12 December 2020

IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia

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12 December 2020

Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.

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12 December 2020

Modeling Parkinson's disease in primates: The MPTP model

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12 December 2020

CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells

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12 December 2020

10.1007/S12035-014-9070-5

Identifiers

DOI

1 reference

PubMed ID

25598354

Dimensions Publication ID

2 September 2017

0 references

1 reference

PubMed ID

25598354