One Hippo and many masters: differential regulation of the Hippo pathway in cancer (Q38238612)

31 August 2017

One Hippo and many masters: differential regulation of the Hippo pathway in cancer (English)

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31 August 2017

5

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31 August 2017

4

Keith T Flaherty

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31 August 2017

David Matallanas

2

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author name string

David Romano

series ordinal

1

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PubMed ID

25109963

31 August 2017

Dennie T Frederick

series ordinal

3

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31 August 2017

1 August 2014

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Biochemical Society Transactions

31 August 2017

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31 August 2017

42

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31 August 2017

4

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31 August 2017

816-821

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Protein kinases of the Hippo pathway: regulation and substrates

31 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The hippo signaling pathway in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Role of YAP/TAZ in mechanotransduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The Drosophila RASSF homolog antagonizes the hippo pathway

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140030

Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The Hippo pathway and human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Raf family kinases: old dogs have learned new tricks

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Role of the Ras-association domain family 1 tumor suppressor gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Phase I/II RAF kinase inhibitors in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Small molecule inhibitors of BRAF in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Resistance to BRAF-targeted therapy in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Suppression of survival signalling pathways by the phosphatase PHLPP

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Targeting RAS signalling pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The dark side of Ras: regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Functional specificity of ras isoforms: so similar but so different

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

The RASSF1A tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Prognostic significance of mammalian sterile 20-like kinase 1 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140030

21 January 2018

Identifiers

DOI

10.1042/BST20140030

1 reference

31 August 2017

1 reference

PubMed ID

25109963