Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options (Q27023596)

Crossref

A. Vultur

series ordinal

2

1 reference

Crossref

M. Herlyn

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

1 December 2011

1 reference

1 reference

71

1 reference

PubMed

issue

23

1 reference

PubMed

page(s)

7137-40

1 reference

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

PubMed

cites work

1 reference

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

21 March 2017

1 reference

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Mutations in GNA11 in uveal melanoma

21 March 2017

1 reference

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

21 March 2017

1 reference

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

21 March 2017

1 reference

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

21 March 2017

1 reference

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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

21 March 2017

1 reference

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Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

21 March 2017

1 reference

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

21 March 2017

1 reference

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Mutations of the BRAF gene in human cancer

21 March 2017

1 reference

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

21 March 2017

1 reference

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

7 April 2017

1 reference

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

7 April 2017

1 reference

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Targeting BRAF in advanced melanoma: a first step toward manageable disease

7 April 2017

1 reference

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Receptor tyrosine kinases and their activation in melanoma.

28 September 2017

1 reference

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PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

28 September 2017

1 reference

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Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells

28 September 2017

1 reference

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Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032.

28 September 2017

1 reference

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RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

28 September 2017

1 reference

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The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance

28 September 2017

1 reference

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28 September 2017

1 reference

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Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells.

28 September 2017

1 reference