Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque. (Q38170338)

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2 March 2020

title

Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque (English)

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2 March 2020

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1

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2 March 2020

Benjamin H. Rotstein

3

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2 March 2020

Steven H. Liang

2

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Thomas Lee Collier

4

object named as

Thomas L Collier

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Neil Vasdev

7

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Nickeisha A Stephenson

5

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author name string

Ivan Greguric

6

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2 March 2020

publication date

11 December 2013

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Journal of Labelled Compounds and Radiopharmaceuticals

2 March 2020

published in

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2 March 2020

volume

57

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2 March 2020

issue

4

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2 March 2020

page(s)

323-331

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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The Mini-Mental State Examination: A Comprehensive Review

21 January 2018

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

21 January 2018

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Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease

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PET imaging of amyloid in Alzheimer's disease.

21 January 2018

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Positron emission tomography radioligands for in vivo imaging of Aβ plaques

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Therapeutics for Alzheimer's disease based on the metal hypothesis

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21 January 2018

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The curious case of clioquinol

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A rapid and efficient preparation of [123I]radiopharmaceuticals using a small HPLC (Rocket) column

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Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.

21 January 2018

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Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

21 January 2018

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Predicting the energetics of osmolyte-induced protein folding/unfolding.

21 January 2018

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21 January 2018

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Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.

21 January 2018

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Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol

21 January 2018

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Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.

21 January 2018

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Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents

21 January 2018

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Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[(18)F]fluoro-myo-inositol

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

21 January 2018

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On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

21 January 2018

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21 January 2018

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Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET.

21 January 2018

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Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity.

21 January 2018

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In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP).

21 January 2018

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21 January 2018

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Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease.

21 January 2018

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The GSK3 hypothesis of Alzheimer's disease

21 January 2018

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21 January 2018

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GSK3beta signalling: casting a wide net in Alzheimer's disease

21 January 2018

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Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease

21 January 2018

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Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.

21 January 2018

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Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.

21 January 2018

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Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT.

21 January 2018

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21 January 2018

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PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue

21 January 2018

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[11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography.

21 January 2018

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Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.

21 January 2018

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Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase

21 January 2018

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

21 January 2018

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The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

21 January 2018

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The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration

21 January 2018

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Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives

21 January 2018

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Synthesis and preliminary evaluation of [18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB2 receptor

21 January 2018

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In vivo tumor grading of prostate cancer using quantitative 111In-capromab pendetide SPECT/CT.

21 January 2018

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Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).

21 January 2018

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Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography.

21 January 2018

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Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease

21 January 2018

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Monoamine oxidase: radiotracer development and human studies

21 January 2018

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Translational neuroimaging: positron emission tomography studies of monoamine oxidase.

21 January 2018

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Radiochemistry devoted to the production of monoamine oxidase (MAO-A and MAO-B) ligands for brain imaging with positron emission tomography

21 January 2018

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Development of new radiopharmaceuticals for imaging monoamine oxidase B.

21 January 2018

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Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain.

21 January 2018

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The synthesis of no-carrier-added DL-4-[18F]fluorodeprenyl via the nucleophilic aromatic substitution reaction.

21 January 2018

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Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).

21 January 2018

1 reference

Synthesis and in vivo studies of a specific monoamine oxidase B inhibitor: 5-[4-(benzyloxy)phenyl]-3-(2-cyanoethyl)- 1,3,4-oxadiazol-[11C]-2(3H)-one.

21 January 2018

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[(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate

21 January 2018

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Neuroinflammation in Alzheimer's disease wanes with age

21 January 2018

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In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders

21 January 2018

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In-vivo measurement of activated microglia in dementia

21 January 2018

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21 January 2018

The translocator protein

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Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography

21 January 2018

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The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa

21 January 2018

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Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography

21 January 2018

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In vivo imaging of neuroinflammation: a comparative study between [(18)F]PBR111, [ (11)C]CLINME and [ (11)C]PK11195 in an acute rodent model

21 January 2018

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Synthesis of [¹¹C]PBR06 and [¹⁸F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO).

21 January 2018

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Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.

21 January 2018

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Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors

21 January 2018

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FMRP mediates mGluR5-dependent translation of amyloid precursor protein

21 January 2018

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Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals

21 January 2018

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Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

21 January 2018

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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP.

21 January 2018

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Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice

21 January 2018

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Radiosynthesis of carbon-11 and fluorine-18 labelled radiotracers to image the ionotropic and metabotropic glutamate receptors.

21 January 2018

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Emerging structure of the nicotinic acetylcholine receptors

21 January 2018

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Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors

21 January 2018

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Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography

21 January 2018

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Biodistribution and radiation dosimetry of the α7 nicotinic acetylcholine receptor ligand [11C]CHIBA-1001 in humans.

21 January 2018

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Preclinical and the first clinical studies on [11C]CHIBA-1001 for mapping alpha7 nicotinic receptors by positron emission tomography.

21 January 2018

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11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements.

21 January 2018

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Molecular imaging of alpha7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743.

21 January 2018

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Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

21 January 2018

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PET imaging of α4β2* nicotinic acetylcholine receptors: quantitative analysis of 18F-nifene kinetics in the nonhuman primate.

21 January 2018

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Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.

21 January 2018

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PET Imaging of nicotinic acetylcholine receptors in baboons with 18F-AZAN, a radioligand with improved brain kinetics

21 January 2018

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Imaging of central nAChReceptors with 2-[18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors.

21 January 2018

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The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor.

21 January 2018

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In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat.

21 January 2018

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Development of radioligands for in vivo imaging of GABA(A)-benzodiazepine receptors

21 January 2018

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21 January 2018

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21 January 2018

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Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET.

21 January 2018

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18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

21 January 2018

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