Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography. (Q36530102)

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scientific article published on 19 December 2012

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English	Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.	scientific article published on 19 December 2012

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19 February 2020

Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography (English)

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19 February 2020

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19 February 2020

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19 February 2020

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Alan A Wilson

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19 February 2020

Oleg Sadovski

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19 February 2020

Jun Parkes

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19 February 2020

Junchao Tong

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19 February 2020

Christopher J Fowler

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19 February 2020

Neil Vasdev

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19 February 2020

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19 December 2012

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19 February 2020

Journal of Medicinal Chemistry

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19 February 2020

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19 February 2020

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19 February 2020

201-209

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19 February 2020

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

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30 September 2017

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

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Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases

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PET radiotracers: crossing the blood-brain barrier and surviving metabolism

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Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation

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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

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Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography.

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Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors

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30 September 2017

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

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Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

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A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

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The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide

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Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

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Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

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30 September 2017

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

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30 September 2017

Structure and function of fatty acid amide hydrolase

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30 September 2017

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

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Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents

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30 September 2017

Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography

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30 September 2017

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

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Brain monoglyceride lipase participating in endocannabinoid inactivation

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30 September 2017

An admonition when measuring the lipophilicity of radiotracers using counting techniques

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30 September 2017

Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography trace for measurement of acetylcholinesterase activity in human brain

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Molecular characterization of human and mouse fatty acid amide hydrolases

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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Synthesis and application of isocyanates radiolabeled with carbon-11.

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Direct fixation of [(11)C]-CO(2) by amines: formation of [(11)C-carbonyl]-methylcarbamates.

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Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain

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21 September 2018

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.

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Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH).

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A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase

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Mechanistic positron emission tomography studies: demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain

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12 December 2020

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[Development of quantitative structure-activity relationships and computer-aided drug design]

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12 December 2020

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A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain

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12 December 2020

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Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

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https://pubmed.ncbi.nlm.nih.gov/23214511

12 December 2020

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10.1021/JM301492Y

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19 February 2020

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24 November 2022

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19 February 2020

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19 February 2020

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