The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications. (Q38104686)

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29 February 2020

title

The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications (English)

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29 February 2020

1

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29 February 2020

Luiz Zerbini

series ordinal

4

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29 February 2020

author name string

Matjaz Vogelsang

series ordinal

2

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29 February 2020

M Iqbal Parker

series ordinal

3

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29 February 2020

language of work or name

English

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publication date

4 June 2013

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International Journal of Cancer

29 February 2020

published in

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29 February 2020

volume

134

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29 February 2020

page(s)

1024-1033

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29 February 2020

issue

5

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Cutting edge: a novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration

29 February 2020

cites work

1 reference

Cell signaling by receptor tyrosine kinases

21 January 2018

1 reference

Signal perception and transduction: the role of protein kinases

21 January 2018

1 reference

The protein tyrosine kinase family of the human genome

21 January 2018

1 reference

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

21 January 2018

1 reference

Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

21 January 2018

1 reference

GAS6 mediates adhesion of cells expressing the receptor tyrosine kinase Axl.

21 January 2018

1 reference

Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity

21 January 2018

1 reference

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

21 January 2018

1 reference

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

21 January 2018

1 reference

Roles of gamma-carboxylation and a sex hormone-binding globulin-like domain in receptor-binding and in biological activities of Gas6.

21 January 2018

1 reference

Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl

21 January 2018

1 reference

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

21 January 2018

1 reference

Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts

21 January 2018

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The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation

21 January 2018

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Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

21 January 2018

1 reference

PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells

21 January 2018

1 reference

Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer

21 January 2018

1 reference

Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL.

21 January 2018

1 reference

Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein

21 January 2018

1 reference

CpG binding protein is crucial for early embryonic development

21 January 2018

1 reference

Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter

21 January 2018

1 reference

Sp3 is a transcriptional repressor of transforming growth factor-beta receptors

21 January 2018

1 reference

Acetylated sp3 is a transcriptional activator

21 January 2018

1 reference

A developmental view of microRNA function

21 January 2018

1 reference

MicroRNAs in development and disease

21 January 2018

1 reference

OncomiRs: the discovery and progress of microRNAs in cancers

21 January 2018

1 reference

miRNAs and their potential for use against cancer and other diseases

21 January 2018

1 reference

How epigenetics can explain human metastasis: a new role for microRNAs

21 January 2018

1 reference

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

21 January 2018

1 reference

Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

21 January 2018

1 reference

Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

21 January 2018

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p53-mediated activation of miRNA34 candidate tumor-suppressor genes.

21 January 2018

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MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

21 January 2018

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Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast

21 January 2018

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Coexpression of Gas6/Axl in human ovarian cancers

21 January 2018

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AXL is an essential factor and therapeutic target for metastatic ovarian cancer

21 January 2018

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Expression of axl in lung adenocarcinoma and correlation with tumor progression

21 January 2018

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Axl receptor tyrosine kinase expression in human lung cancer cell lines correlates with cellular adhesion

21 January 2018

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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

21 January 2018

1 reference

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

21 January 2018

1 reference

Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

21 January 2018

1 reference

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

21 January 2018

1 reference

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

21 January 2018

1 reference

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

21 January 2018

1 reference

AXL is a potential target for therapeutic intervention in breast cancer progression.

21 January 2018

1 reference

Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

21 January 2018

1 reference

Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells

21 January 2018

1 reference

Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL.

21 January 2018

1 reference

MicroRNA expression and clinical outcome of small cell lung cancer

21 January 2018

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

21 January 2018

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An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

21 January 2018

1 reference

Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth

21 January 2018

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The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.

21 January 2018

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Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.

21 January 2018

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GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.

21 January 2018

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Profiling of antibody production against xenograft-released proteins by protein microarrays discovers prostate cancer markers

21 January 2018

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Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway

21 January 2018

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A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

21 January 2018

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ABL regulation by AXL promotes cisplatin resistance in esophageal cancer

21 January 2018

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The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

21 January 2018

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Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer

21 January 2018

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Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

21 January 2018

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Phosphoproteomic screen identifies potential therapeutic targets in melanoma

21 January 2018

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Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

21 January 2018

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Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase.

21 January 2018

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Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma

21 January 2018

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The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target

21 January 2018

1 reference

Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer

21 January 2018

1 reference

Differential expression of Axl in hepatocellular carcinoma and correlation with tumor lymphatic metastasis

21 January 2018

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AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.

21 January 2018

1 reference

Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma

21 January 2018

1 reference

Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival.

21 January 2018

1 reference

Expression of the proto-oncogene Axl in renal cell carcinoma

21 January 2018

1 reference

Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer

21 January 2018

1 reference

Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl

21 January 2018

1 reference

Expression of the Axl receptor tyrosine kinase in human thyroid carcinoma

21 January 2018

1 reference

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma

21 January 2018

1 reference

Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme

21 January 2018

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Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival

21 January 2018

1 reference

Biological properties and gene expression associated with metastatic potential of human osteosarcoma

21 January 2018

1 reference

Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers

21 January 2018

1 reference

Clinical implications of coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine leiomyoma

21 January 2018

1 reference

Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity

21 January 2018

1 reference

Multiple roles for the receptor tyrosine kinase axl in tumor formation

21 January 2018

1 reference

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

21 January 2018

1 reference

Epithelial-mesenchymal transitions in tumour progression

21 January 2018

1 reference

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

21 January 2018

1 reference

Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model

21 January 2018

1 reference

Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells

21 January 2018

1 reference

Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.

21 January 2018

1 reference

Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.

21 January 2018

1 reference

Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence

21 January 2018

1 reference

Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy

21 January 2018

1 reference

21 January 2018

Cancer micrometastases

1 reference

21 January 2018

Cancer statistics, 1999.

1 reference

The discovery of receptor tyrosine kinases: targets for cancer therapy

21 January 2018

1 reference

Drug discovery in the kinase inhibitory field using the Nested Chemical Library technology.

21 January 2018

1 reference

Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles

21 January 2018

1 reference

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

21 January 2018

1 reference

Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors

21 January 2018

1 reference

Targeting Axl with an high-affinity inhibitory aptamer.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.28246

1 reference

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