An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies (Q39684120)

14 September 2017

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies (English)

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14 September 2017

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X Ye

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Y Li

2

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S Stawicki

3

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S Couto

4

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J Eastham-Anderson

5

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D Kallop

6

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R Weimer

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Y Wu

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L Pei

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14 September 2017

language of work or name

English

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publication date

5 July 2010

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5254-5264

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https://scigraph.springernature.com/pub.10.1038/onc.2010.268

14 September 2017

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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

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R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

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Multiple roles for the receptor tyrosine kinase axl in tumor formation

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Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia

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Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme

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The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target

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An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

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High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold

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Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.

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Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.

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A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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Tumour-educated macrophages promote tumour progression and metastasis

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

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Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.

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Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer

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Coexpression of Gas6/Axl in human ovarian cancers

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Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.

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Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

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Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.268

AXL is a potential target for therapeutic intervention in breast cancer progression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.268

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.268

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14 September 2017

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