Hypoxia-inducible factors as key regulators of tumor inflammation (Q38051286)

27 August 2017

Hypoxia-inducible factors as key regulators of tumor inflammation (English)

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27 August 2017

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2

Ben Wielockx

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27 August 2017

Soulafa Mamlouk

1

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PubMed ID

23055435

27 August 2017

language of work or name

English

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publication date

2 November 2012

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International Journal of Cancer

27 August 2017

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27 August 2017

132

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27 August 2017

12

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27 August 2017

2721-2729

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The histological structure of some human lung cancers and the possible implications for radiotherapy

27 August 2017

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Exploiting tumour hypoxia in cancer treatment

21 January 2018

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Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

21 January 2018

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

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Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

21 January 2018

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Hypoxia in cancer: significance and impact on clinical outcome

21 January 2018

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

21 January 2018

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

21 January 2018

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Drug penetration in solid tumours

21 January 2018

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Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.

21 January 2018

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The impact of O2 availability on human cancer

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

21 January 2018

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Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

21 January 2018

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

21 January 2018

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Hypoxia-inducible factors and the response to hypoxic stress

21 January 2018

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Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

21 January 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

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Purification and characterization of hypoxia-inducible factor 1

21 January 2018

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

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Hydroxylation of HIF-1: oxygen sensing at the molecular level

21 January 2018

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

21 January 2018

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

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Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

21 January 2018

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

21 January 2018

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Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

21 January 2018

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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

21 January 2018

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Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ

21 January 2018

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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

21 January 2018

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Hypoxia--a key regulatory factor in tumour growth

21 January 2018

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Stabilisation and knockdown of HIF--two distinct ways comparably important in radiotherapy

21 January 2018

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Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

21 January 2018

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Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity

21 January 2018

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Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer

21 January 2018

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Tumor stroma and regulation of cancer development

21 January 2018

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In memoriam of Rudolf virchow: a historical retrospective including aspects of inflammation, infection and neoplasia.

21 January 2018

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21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Cancer-related inflammation

21 January 2018

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Inflammation and cancer: how hot is the link?

21 January 2018

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Inflammation and colon cancer

21 January 2018

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Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene

21 January 2018

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Immunity, Inflammation, and Cancer

21 January 2018

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

21 January 2018

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Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma

21 January 2018

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Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages

21 January 2018

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

21 January 2018

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Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions.

21 January 2018

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Tumour-associated leucocytes: friends or foes in breast carcinoma

21 January 2018

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The role of myeloid cells in the promotion of tumour angiogenesis

21 January 2018

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Adaptive immunity maintains occult cancer in an equilibrium state

21 January 2018

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Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

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Ovarian cancer progression is controlled by phenotypic changes in dendritic cells

21 January 2018

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Smoldering and polarized inflammation in the initiation and promotion of malignant disease

21 January 2018

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Hypoxia potentiates glioma-mediated immunosuppression

21 January 2018

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Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide

21 January 2018

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

21 January 2018

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Macrophages, innate immunity and cancer: balance, tolerance, and diversity

21 January 2018

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Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies

21 January 2018

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Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

21 January 2018

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CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

21 January 2018

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Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

21 January 2018

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Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

21 January 2018

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IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice

21 January 2018

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Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

21 January 2018

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Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase

21 January 2018

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Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

21 January 2018

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

21 January 2018

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

21 January 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

21 January 2018

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Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation

21 January 2018

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HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

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HIF-1alpha expression regulates the bactericidal capacity of phagocytes

21 January 2018

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

21 January 2018

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Immunosuppressive strategies that are mediated by tumor cells

21 January 2018

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Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.

21 January 2018

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Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts

21 January 2018

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TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells

21 January 2018

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Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes

21 January 2018

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The mouse gene for hypoxia-inducible factor-1alpha--genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence

21 January 2018

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Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues

21 January 2018

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Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling.

21 January 2018

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

21 January 2018

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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

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The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity

21 January 2018

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Myeloid-derived suppressor cells: a double-edged sword?

21 January 2018

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Myeloid-derived suppressor cells as regulators of the immune system

21 January 2018

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Altered macrophage differentiation and immune dysfunction in tumor development

21 January 2018

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Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy

21 January 2018

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HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

21 January 2018

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Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function

21 January 2018

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Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils

21 January 2018

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HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT.

21 January 2018

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Cancer immunotherapy via dendritic cells

21 January 2018

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Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

21 January 2018

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

21 January 2018

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Distinct role of macrophages in different tumor microenvironments

21 January 2018

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Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis.

21 January 2018

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Tumour-educated macrophages promote tumour progression and metastasis

21 January 2018

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Macrophage diversity enhances tumor progression and metastasis

21 January 2018

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer

21 January 2018

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Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

21 January 2018

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Hypoxia-inducible factor-2α regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis

21 January 2018

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Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma

21 January 2018

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Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy

21 January 2018

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Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice

21 January 2018

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Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

21 January 2018

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HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation

21 January 2018

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Bone marrow cells in the 'pre-metastatic niche': within bone and beyond

21 January 2018

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A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth

21 January 2018

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Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

21 January 2018

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

21 January 2018

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Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

21 January 2018

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Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy

21 January 2018

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Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors

21 January 2018

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Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1α in cancer cells

21 January 2018

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Interdependence of hypoxic and innate immune responses

21 January 2018

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Tumor-associated macrophages in breast cancer.

21 January 2018

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

21 January 2018

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Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.27901

1 reference

27 August 2017

1 reference

PubMed ID

23055435