HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation (Q39392726)

11 September 2017

HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation (English)

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11 September 2017

3

Markus M Heimesaat

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11 September 2017

5

Ben Wielockx

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11 September 2017

Anne Klotzsche-von Ameln

series ordinal

1

1 reference

PubMed ID

22354010

11 September 2017

Antje Muschter

series ordinal

2

1 reference

PubMed ID

22354010

11 September 2017

Georg Breier

series ordinal

4

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11 September 2017

1 February 2012

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Cancer Biology and Therapy

11 September 2017

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11 September 2017

13

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11 September 2017

4

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11 September 2017

216-223

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The impact of O2 availability on human cancer

11 September 2017

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https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

MMPs as therapeutic targets--still a viable option?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Hypoxia augments gelatinase activity in a variety of adenocarcinomas in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCBT.13.4.18830

21 January 2018

Identifiers

DOI

10.4161/CBT.13.4.18830

1 reference

11 September 2017

1 reference

PubMed ID

22354010