AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches (Q38033116)

27 August 2017

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches (English)

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27 August 2017

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Megan A Hatlen

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27 August 2017

Lan Wang

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2

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27 August 2017

Stephen D Nimer

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3

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27 August 2017

language of work or name

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9 August 2012

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27 August 2017

Frontiers of medicine

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27 August 2017

6

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27 August 2017

248-262

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27 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s11684-012-0206-6

27 August 2017

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cites work

Complementing mutations in core binding factor leukemias: from mouse models to clinical applications

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Gene targeting reveals a crucial role for MTG8 in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Inducible gene targeting in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

21 January 2018

Role of FLT3 in leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Molecular genetics of acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Molecular genetics of human leukemias: new insights into therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Granulocytic sarcoma is associated with the 8;21 translocation in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

p21WAF1 mutations and human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Absence of p21(CIP 1), p27(KIP 1) and p 57(KIP 2) methylation in MDS and AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Structure and expression of the human MTG8/ETO gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Current therapeutic strategies for acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The functions of animal microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

MicroRNAs and their regulatory roles in animals and plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

MicroRNAs: emerging key regulators of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Proteomics of acute myeloid leukaemia: Cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Implications of NRAS mutations in AML: a study of 2502 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The AML1/ETO fusion protein activates transcription of BCL-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Identification of AML1-ETO modulators by chemical genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Remission of acute myeloblastic leukemia after severe pneumonia treated with high-dose methylprednisolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Post-translational modifications of Runx1 regulate its activity in the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

The 8;21 translocation in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/AML1-ETO

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-012-0206-6

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

21 January 2018

1 reference

12 December 2020

The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor

1 reference

12 December 2020

Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor

1 reference

12 December 2020

Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

1 reference

12 December 2020

High degree of myeloid differentiation and granulocytosis is associated with t(8;21) smoldering leukemia

1 reference

12 December 2020

Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.

1 reference

12 December 2020

Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias

1 reference

12 December 2020

An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivin.

1 reference

12 December 2020

Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation

1 reference

12 December 2020

ESMO Minimum Clinical Recommendations for the diagnosis, treatment and follow-up of acute myeloblastic leukemia (AML) in adult patients

1 reference

12 December 2020

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

1 reference

12 December 2020

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

1 reference

12 December 2020

Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B

1 reference

12 December 2020

Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients

1 reference

12 December 2020

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia

1 reference

12 December 2020

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1 reference

12 December 2020

Molecular analysis of cyclin-dependent kinase inhibitors in human leukemias

1 reference

12 December 2020

The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

1 reference

12 December 2020

10.1007/S11684-012-0206-6

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27 August 2017

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