AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. (Q33762738)

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7 January 2020

title

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec (English)

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7 January 2020

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1

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7 January 2020

Guangbiao Zhou

2

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7 January 2020

Guangbiao Zhou

3

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7 January 2020

author name string

Tong Yin

4

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7 January 2020

Bing Chen

5

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7 January 2020

Jing-Yi Shi

6

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7 January 2020

Wen-Xue Liang

7

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7 January 2020

Xiao-Long Jin

8

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7 January 2020

Jian-Hua You

9

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7 January 2020

Guang Yang

10

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7 January 2020

Zhi-Xiang Shen

11

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7 January 2020

Jue Chen

12

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7 January 2020

Shu-Min Xiong

13

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7 January 2020

Guo-Qiang Chen

14

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7 January 2020

Feng Xu

15

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7 January 2020

Yi-Wei Liu

16

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7 January 2020

Zhu Chen

17

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7 January 2020

Sai-Juan Chen

18

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7 January 2020

language of work or name

English

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publication date

13 January 2005

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7 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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7 January 2020

volume

102

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7 January 2020

page(s)

1104-1109

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7 January 2020

issue

4

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Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

7 January 2020

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An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

22 June 2018

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Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

22 June 2018

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22 June 2018

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ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

22 June 2018

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

22 June 2018

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22 June 2018

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

22 June 2018

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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21 January 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.

30 October 2018

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Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

30 October 2018

1 reference

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Transforming growth factor-beta 1 interferes with the proliferation-inducing activity of stem cell factor in myelogenous leukemia blasts through functional down-regulation of the c-kit proto-oncogene product.

30 October 2018

1 reference

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

30 October 2018

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Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

21 January 2018

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12 December 2020

AML: immunophenotypic heterogeneity and prognostic significance of c-kit expression

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12 December 2020

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia

1 reference

12 December 2020

C-kit mutations in core binding factor leukemias

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12 December 2020

Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MTG8: overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF

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12 December 2020

Feasibility and clinical significance of real-time quantitative RT-PCR assay of PML-RARalpha fusion transcript in patients with acute promyelocytic leukemia

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12 December 2020

C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0408831102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15650049%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

0 references

1 reference

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7 January 2020

1 reference