E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions (Q38030236)

27 August 2017

E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions (English)

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27 August 2017

6

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27 August 2017

14

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27 August 2017

16

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27 August 2017

Soraia Melo

8

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Patrícia Carneiro

Patrícia Carneiro

1

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Patrícia Oliveira

Patrícia Oliveira

9

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Joana Carvalho

Joana Carvalho

5

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Joana Caldeira

Joana Caldeira

4

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Marina Leite

Marina Leite

7

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Maria José Oliveira

Maria José Oliveira

11

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Ceu Figueiredo

Céu Figueiredo

13

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Joana Figueiredo

Joana Figueiredo

3

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Carla Oliveira

Carla Oliveira

15

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Fatima Carneiro

Fátima Carneiro

12

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Joana Simões Correia

10

Joana Simões-Correia

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PubMed ID

22841718

27 August 2017

Maria Sofia Fernandes

2

Maria Sofia Fernandes

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PubMed ID

22841718

27 August 2017

language of work or name

English

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publication date

25 July 2012

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27 August 2017

9

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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27 August 2017

586

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27 August 2017

18

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27 August 2017

2981-2989

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Nature meets nurture: molecular genetics of gastric cancer.

27 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Genetic aspects of gastric cancer instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Genetics, pathology, and clinics of familial gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Gastric cancer: new genetic developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Molecular basis of gastric cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

After Helicobacter pylori, genetic susceptibility to gastric carcinoma revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Salt intake and gastric cancer risk according to Helicobacter pylori infection, smoking, tumour site and histological type

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Management of advanced gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Treatment of resectable gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Snail1 links transcriptional control with epigenetic regulation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The cell-cell adhesion molecule E-cadherin.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cadherins in development and cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Functional correlation between cell adhesive properties and some cell surface proteins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Morphogenetic roles of classic cadherins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Structural basis of cell-cell adhesion by cadherins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Regulation of cadherin-mediated adhesion in morphogenesis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cadherins: a molecular family important in selective cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Remodeling of the adherens junctions during morphogenesis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin null mutant embryos fail to form a trophectoderm epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Epigenetic versus genetic alterations in the inactivation of E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin is a WT1 target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The ins and outs of E-cadherin trafficking

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Modulation of E-cadherin function and dysfunction by N-glycosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

N-glycosylation affects the molecular organization and stability of E-cadherin junctions

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Biological influence of Hakai in cancer: a 10-year review

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

A core function for p120-catenin in cadherin turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Involvement of members of the cadherin superfamily in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Soluble cadherins as cancer biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Mechanisms of motility in metastasizing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin germline mutations in familial gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Germline CDH1 deletions in hereditary diffuse gastric cancer families

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Pathology and genetics of familial gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Germline E-cadherin mutations in familial lobular breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Role of E-cadherin N-glycosylation profile in a mammary tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Adhesion molecule signalling: not always a sticky business.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Expression of seven main Rho family members in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin mutations and cell motility: a genotype-phenotype correlation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Clinicopathological significance of E-cadherin, VEGF, and MMPs in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Helicobacter pylori infection and the development of gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Helicobacter pylori infection targets adherens junction regulatory proteins and results in increased rates of migration in human gastric epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Effects of Helicobacter pylori on the cadherin-catenin complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Hereditary diffuse gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Collective cell migration in morphogenesis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Matrix metalloproteinases in tumorigenesis: an evolving paradigm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Hereditary diffuse gastric cancer: surgery, surveillance and unanswered questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

Glycosylation features of gastric carcinoma initiation and progression. A review with emphasis on simple mucin-type carbohydrates and histo-blood group antigens of the Lewis system

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.07.045

10.1016/J.FEBSLET.2012.07.045

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22841718