From excess adiposity to insulin resistance: the role of free fatty acids (Q38011507)

27 August 2017

From excess adiposity to insulin resistance: the role of free fatty acids (English)

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27 August 2017

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Cristiano Capurso

1

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PubMed ID

22609131

27 August 2017

Antonio Capurso

series ordinal

2

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27 August 2017

15 May 2012

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27 August 2017

Vascular Pharmacology

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27 August 2017

57

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27 August 2017

91-97

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27 August 2017

2-4

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

27 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Associazione di iperlipemia, diabete mellito e obesita' di medio grado

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adiposopathy is "sick fat" a cardiovascular disease?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adiposopathy: why do adiposity and obesity cause metabolic disease?

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adipose tissue, inflammation, and cardiovascular disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

7 January 2021

The metabolic syndrome

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Failure of adipocyte differentiation causes type II diabetes mellitus?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Is obesity an inflammatory condition?

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

7 January 2021

The metabolic syndrome

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Effect of fatty acids on glucose production and utilization in man

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

The relation of body fat mass and distribution to markers of chronic inflammation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adipose tissue function and dysfunction: organ cross talk and metabolic risk

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

A central role for JNK in obesity and insulin resistance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Inflammatory pathways and insulin action

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Inflammation and metabolic disorders

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Subcutaneous and visceral adipose tissue: structural and functional differences

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Interaction between glucose and free fatty acid metabolism in human skeletal muscle

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

The metabolic syndrome: one step forward, two steps back

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Prevention of fat-induced insulin resistance by salicylate

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Knockout of PKC alpha enhances insulin signaling through PI3K

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

A pathogenic role of visceral fat beta 3-adrenoceptors in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

In vitro neovasculogenic potential of resident adipose tissue precursors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Effects of body fat distribution on regional lipolysis in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Prevalence of overweight and obesity in the United States, 1999-2004

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Modulation of insulin action.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Ph

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Interplay between insulin and nutrients in the regulation of translation factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

The insulin resistance syndrome: definition and dietary approaches to treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Muscle and adipose tissue morphology and metabolism in Cushing's syndrome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Metabolism of adipose tissue in intraabdominal depots of nonobese men and women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin signalling and the regulation of glucose and lipid metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin sensitivity: modulation by nutrients and inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Biological action of leptin as an angiogenic factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Inhibition of insulin receptor signaling by TNF: potential role in obesity and non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Dynamics of fat cell turnover in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adipose tissue macrophages: their role in adipose tissue remodeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adipokines: inflammation and the pleiotropic role of white adipose tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Obesity is associated with macrophage accumulation in adipose tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Obesity-induced inflammatory changes in adipose tissue.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Insulin signaling in health and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Adipose tissue, insulin action and vascular disease: inflammatory signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

Human adipose tissue is a source of multipotent stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VPH.2012.05.003

10.1016/J.VPH.2012.05.003

7 January 2021

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22609131