Inflammation and metabolic disorders (Q27860923)

Childhood obesity and a diabetes epidemic

Europe PubMed Central

title

Inflammation and metabolic disorders (English)

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1

Gökhan S Hotamisligil

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language of work or name

English

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publication date

14 December 2006

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published in

Nature

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volume

444

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page(s)

860-7

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issue

7121

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cites work

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Homology between the mammalian liver and the Drosophila fat body.

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The immune response of Drosophila melanogaster

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Function of GATA transcription factors in preadipocyte-adipocyte transition

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Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway

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Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Inflammation and insulin resistance

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Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila

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Impact of obesity on treatment of chronic hepatitis C.

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Inflammation: the link between insulin resistance, obesity and diabetes

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

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Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

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The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

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The expression of TNF alpha by human muscle. Relationship to insulin resistance

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Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans.

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Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

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Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis

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Obesity is associated with macrophage accumulation in adipose tissue

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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IKK-beta links inflammation to obesity-induced insulin resistance

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Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis

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7 January 2021

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

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7 January 2021

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

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7 January 2021

Nuclear receptors and lipid physiology: opening the X-files

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7 January 2021

Combinatorial roles of nuclear receptors in inflammation and immunity

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7 January 2021

Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors

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7 January 2021

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

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7 January 2021

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

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7 January 2021

The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes

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7 January 2021

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

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7 January 2021

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

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7 January 2021

PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth

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7 January 2021

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein

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7 January 2021

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

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7 January 2021

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease

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7 January 2021

The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation

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7 January 2021

Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

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7 January 2021

Critical nodes in signalling pathways: insights into insulin action

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7 January 2021

IRS proteins and the common path to diabetes

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7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

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7 January 2021

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

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7 January 2021

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

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7 January 2021

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

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7 January 2021

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

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7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

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7 January 2021

Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

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7 January 2021

Signal transduction by tumor necrosis factor and its relatives

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7 January 2021

A central role for JNK in obesity and insulin resistance

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

PKC-theta knockout mice are protected from fat-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Endoplasmic reticulum stress signaling in disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

The mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Increased oxidative stress in obesity and its impact on metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Reactive oxygen species have a causal role in multiple forms of insulin resistance

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Biochemistry and molecular cell biology of diabetic complications

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Mitochondrial dysfunction and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Peroxisome proliferator-activated receptors: from genes to physiology

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells

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https://api.crossref.org/works/10.1038%2FNATURE05485

7 January 2021

Identifiers

DOI

10.1038/NATURE05485

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

98652

1042166283

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98652

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference