Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer (Q37941372)

25 August 2017

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title

Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer (English)

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25 August 2017

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H Werner

1

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PubMed ID

21963847

25 August 2017

language of work or name

English

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publication date

3 October 2011

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25 August 2017

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25 August 2017

31

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25 August 2017

2703-2714

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25 August 2017

22

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https://scigraph.springernature.com/pub.10.1038/onc.2011.447

25 August 2017

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cites work

BRCA1–Sp1 interactions in transcriptional regulation of the IGF‐IR gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

New plays in the p53 theater

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The IGF‐1 receptor in cancer biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

IGF and insulin receptor signaling in breast cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin receptor and cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Cellular functions of the BRCA tumour-suppressor proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Serum microRNAs as non-invasive biomarkers for cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Targeting the IGF1 axis in cancer proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Induction of the growth inhibitor IGF-binding protein 3 by p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Regulation of cancer cell metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FONC.2011.447

31 March 2020

https://api.crossref.org/works/10.1038%2FONC.2011.447

inferred from DOI database lookup

7 January 2021

based on heuristic

Nutrition, metabolic factors and cancer risk

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The EWS-WT1 gene fusion in desmoplastic small round cell tumor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Defining the role of mTOR in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Canalization of development by microRNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

IGF1R mutations as cause of SGA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

IGF signaling defects as causes of growth failure and IUGR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Regulation of p53 in response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Diabetic retinopathy in two patients with congenital IGF-I deficiency (Laron syndrome).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

p53, the cellular gatekeeper for growth and division

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

MicroRNAs as therapeutic targets in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

BRCA mutations in the management of breast cancer: the state of the art.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Akt-dependent transformation: there is more to growth than just surviving

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin and insulin-like growth factor signalling in neoplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Obesity and cancer risk: the role of the insulin-IGF axis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The role of the IGF system in cancer growth and metastasis: overview and recent insights

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Targeting insulin-like growth factor 1 receptor in sarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Apoptosis promotes early tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

A heterozygous mutation of the insulin-like growth factor-I receptor causes retention of the nascent protein in the endoplasmic reticulum and results in intrauterine and postnatal growth retardation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

On the Origin of Cancer Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The insulin-like growth factor-I receptor as an oncogene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Basic and clinical significance of IGF-I-induced signatures in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The IGFI receptor gene: a molecular target for disrupted transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

P63 and P73: P53 mimics, menaces and more

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.447

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.447

1 reference

25 August 2017

1 reference

PubMed ID

21963847