Insulin and insulin-like growth factor signalling in neoplasia (Q29619495)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19029956

30 April 2017

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Pollak M

1

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30 April 2017

publication date

December 2008

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19029956

30 April 2017

language of work or name

1 reference

30 April 2017

published in

Nature Reviews Cancer

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30 April 2017

volume

8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19029956

30 April 2017

issue

12

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30 April 2017

page(s)

915-28

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publication type of scholarly work

30 April 2017

review article

1 reference

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

Europe PubMed Central

cites work

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Metformin and reduced risk of cancer in diabetic patients

1 May 2017

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Tumor cell metabolism: cancer's Achilles' heel

1 May 2017

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

1 May 2017

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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

1 May 2017

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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

1 May 2017

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Cellular actions of the insulin-like growth factor binding proteins

1 May 2017

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Induction of the growth inhibitor IGF-binding protein 3 by p53

1 May 2017

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Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist

1 May 2017

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Long-term mortality after gastric bypass surgery

1 May 2017

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Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects

1 May 2017

1 reference

Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden

1 May 2017

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Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

1 May 2017

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

1 May 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 May 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

1 May 2017

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 May 2017

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

1 May 2017

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Central nervous system control of food intake and body weight

1 May 2017

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AMPK and PPARdelta agonists are exercise mimetics

1 May 2017

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Insulin-like growth factor II precursor gene organization in relation to insulin gene family

1 May 2017

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 May 2017

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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

1 May 2017

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Structure and evolution of the insulin gene

1 May 2017

1 reference

Insulin and its receptor: structure, function and evolution

31 March 2020

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Quantitative mass spectrometry identifies insulin signaling targets in C. elegans

31 March 2020

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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

31 March 2020

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Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

31 March 2020

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Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

31 March 2020

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Insulin-like growth factors and neoplasia.

31 March 2020

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The type 1 insulin-like growth factor receptor pathway

31 March 2020

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Disrupting insulin-like growth factor signaling as a potential cancer therapy

31 March 2020

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Glucose metabolism and cancer

31 March 2020

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An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

31 March 2020

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Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

31 March 2020

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Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

31 March 2020

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The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer.

31 March 2020

1 reference

Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces or

31 March 2020

1 reference

A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.

31 March 2020

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Hormone responsive human breast cancer in long-term tissue culture: effect of insulin

31 March 2020

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The role of insulin receptors and IGF-I receptors in cancer and other diseases

31 March 2020

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Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

31 March 2020

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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion

31 March 2020

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Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

31 March 2020

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Gene expression profiles in normal and cancer cells

31 March 2020

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Antiproliferative action of vitamin D-related compounds and insulin-like growth factor-binding protein 5 accumulation

31 March 2020

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Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells

31 March 2020

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Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer

31 March 2020

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Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer

31 March 2020

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PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2.

31 March 2020

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IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells

31 March 2020

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IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

31 March 2020

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Doctors seek to prevent breast cancer recurrence by lowering insulin levels.

31 March 2020

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Presence of somatomedin receptors on primary human breast and colon carcinomas

31 March 2020

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Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

31 March 2020

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A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model

31 March 2020

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

31 March 2020

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Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors

31 March 2020

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In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

31 March 2020

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

31 March 2020

1 reference

IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor

31 March 2020

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Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.

31 March 2020

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Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts

31 March 2020

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Cancers associated with acromegaly

31 March 2020

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Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report

31 March 2020

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Body shape throughout life and correlations with IGFs and GH

31 March 2020

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Insulin-like growth factor I and leptin in umbilical cord plasma and infant birth size at term

31 March 2020

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Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort.

31 March 2020

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High birthweight as a predictor of prostate cancer risk.

31 March 2020

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Height, leg length, and cancer risk: a systematic review

31 March 2020

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Growth patterns and the risk of breast cancer in women

31 March 2020

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Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density

31 March 2020

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Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels

31 March 2020

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Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study

31 March 2020

1 reference

Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

31 March 2020

1 reference

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

31 March 2020

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Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer

31 March 2020

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Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer

31 March 2020

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Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study

31 March 2020

1 reference

Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II

31 March 2020

1 reference

Commentary: implications of the frequent occurrence of occult carcinoma of the prostate

31 March 2020

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Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort

31 March 2020

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Implications for Prostate Cancer of Insulin-Like Growth Factor-I (IGF-I) Genetic Variation and Circulating IGF-I Levels

31 March 2020

1 reference

IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer

31 March 2020

1 reference

Functionally significant insulin-like growth factor I receptor mutations in centenarians

31 March 2020

1 reference

Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis

31 March 2020

1 reference

Are findings from studies of obesity and prostate cancer really in conflict?

31 March 2020

1 reference

Metabolic syndrome, hyperinsulinemia, and colon cancer: a review

31 March 2020

1 reference

Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

31 March 2020

1 reference

An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer

31 March 2020

1 reference

The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

31 March 2020

1 reference

Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 Receptor monoclonal antibody CP-751,871 in patients with multiple myeloma

31 March 2020

1 reference

Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors

31 March 2020

1 reference

Potential Applications for Circulating Tumor Cells Expressing the Insulin-Like Growth Factor-I Receptor

31 March 2020

1 reference

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance

31 March 2020

1 reference

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

31 March 2020

1 reference

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

31 March 2020

1 reference

Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer

31 March 2020

1 reference

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1

31 March 2020

1 reference

Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.

31 March 2020

1 reference

Neither LKB1 nor AMPK are the direct targets of metformin

31 March 2020

1 reference

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

31 March 2020

1 reference

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

31 March 2020

1 reference

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

31 March 2020

1 reference

Cancer and aging: more puzzles, more promises?

31 March 2020

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In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.

31 March 2020

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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

31 March 2020

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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

31 March 2020

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

31 March 2020

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Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

31 March 2020

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AMP-activated protein kinase is essential for survival in chronic hypoxia

31 March 2020

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Metformin slows down aging and extends life span of female SHR mice.

31 March 2020

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

31 March 2020

1 reference

Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

31 March 2020

1 reference

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

31 March 2020

1 reference

The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer

31 March 2020

1 reference

Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.

31 March 2020

1 reference

Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism

31 March 2020

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Fasting serum glucose level and cancer risk in Korean men and women

31 March 2020

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Inhaled insulin's last gasp?

31 March 2020

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A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

31 March 2020

1 reference

Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study

31 March 2020

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Insulin sensitivity during combined androgen blockade for prostate cancer

31 March 2020

1 reference

Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer

31 March 2020

1 reference

Dietary energy balance modulates signaling through the Akt/mammalian target of rapamycin pathways in multiple epithelial tissues

31 March 2020

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Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver

31 March 2020

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Effects of energy balance on cancer in genetically altered mice

31 March 2020

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LKB1: a sweet side to Peutz-Jeghers syndrome?

31 March 2020

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AMPK and Raptor: matching cell growth to energy supply.

31 March 2020

1 reference

Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice

31 March 2020

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Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

31 March 2020

1 reference

Lifetime recreational exercise activity and breast cancer risk among black women and white women

31 March 2020

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Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in rats

31 March 2020

1 reference

Secular changes in body height and weight of Portuguese boys over one century

31 March 2020

1 reference

Optimization of whole-body positron emission tomography imaging by using delayed 2-deoxy-2-[F-18]fluoro-D: -glucose Injection following I.V. Insulin in diabetic patients

31 March 2020

1 reference

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

31 March 2020

1 reference

The level of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of (111)In-IGF-1(E3R) in vivo and the clonogenic survival of breast cancer cells exposed in vitro to trastuzumab (Herceptin).

31 March 2020

1 reference

A mysterious something: the discovery of insulin and the 1923 Nobel Prize for Frederick G. Banting (1891-1941) and John J.R. Macleod (1876-1935).

31 March 2020

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Effect of insulin and cortisol on organ cultures of adult mouse mammary gland

31 March 2020

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Cell proliferation induced by insulin in organ culture of rat mammary carcinoma

31 March 2020

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Sequence of cDNA encoding human insulin-like growth factor I precursor

31 March 2020

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Genetic Variation in the Human Insulin Gene

31 March 2020

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Sequence of the human insulin gene

31 March 2020

1 reference

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

31 March 2020

1 reference

The role of the IGF system in cancer growth and metastasis: overview and recent insights

31 March 2020

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Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors

31 March 2020

1 reference

Commercial interest waxes for IGF-1 blockers

31 March 2020

1 reference

Energy balance and carcinogenesis: underlying pathways and targets for intervention

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19029956

31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions publication ID

1050986935

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19029956

PubMed publication ID

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017