MicroRNAs as therapeutic targets in cancer (Q37855085)

24 August 2017

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title

MicroRNAs as therapeutic targets in cancer (English)

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24 August 2017

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2

Carlo M Croce

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24 August 2017

S Patrick Nana-Sinkam

series ordinal

1

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24 August 2017

4 February 2011

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24 August 2017

Translational Research

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24 August 2017

157

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24 August 2017

216-225

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24 August 2017

4

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

24 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNAs: genomics, biogenesis, mechanism, and function

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Causes and consequences of microRNA dysregulation in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA biogenesis and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNAs: fundamental facts and involvement in human diseases

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Microprocessor of microRNAs: regulation and potential for therapeutic intervention

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Modulation of microRNA processing by p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Overexpression of Dicer in precursor lesions of lung adenocarcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Impaired microRNA processing enhances cellular transformation and tumorigenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Inherited polymorphisms in the RNA-mediated interference machinery affect microRNA expression and lung cancer survival

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNAs and the hallmarks of cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

7 January 2021

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

RAS is regulated by the let-7 microRNA family

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

The let-7 microRNA represses cell proliferation pathways in human cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Regression of murine lung tumors by the let-7 microRNA

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

miR-15 and miR-16 induce apoptosis by targeting BCL2

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Implications of micro-RNA profiling for cancer diagnosis.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A MicroRNA targeting dicer for metastasis control

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Reprogramming of miRNA networks in cancer and leukemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA signature predicts survival and relapse in lung cancer.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA expression differentiates histology and predicts survival of lung cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNAs in the pathogeny of chronic lymphocytic leukaemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Modulation of mismatch repair and genomic stability by miR-155

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

The role of microRNAs in liver cancer progression.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA expression, survival, and response to interferon in liver cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Expression profiling identifies microRNA signature in pancreatic cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Real-time expression profiling of microRNA precursors in human cancer cell lines

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA signatures in human ovarian cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Targeting microRNAs in cancer: rationale, strategies and challenges

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA sponges: progress and possibilities

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Emerging roles for natural microRNA sponges

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeutics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNAs modulate the chemosensitivity of tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

MicroRNA expression profiles for the NCI-60 cancer cell panel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Circulating microRNAs as stable blood-based markers for cancer detection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Detection of microRNA expression in human peripheral blood microvesicles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2011.01.013

10.1016/J.TRSL.2011.01.013

7 January 2021

Identifiers

DOI

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24 August 2017

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PubMed ID

21420032