Limitations to the structure-based design of HIV-1 vaccine immunogens (Q37910841)

25 August 2017

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title

Limitations to the structure-based design of HIV-1 vaccine immunogens (English)

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25 August 2017

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Marc H V Van Regenmortel

series ordinal

1

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25 August 2017

1 September 2011

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Journal of Molecular Recognition

25 August 2017

13

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based on heuristic

inferred from page(s)

published in

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25 August 2017

24

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25 August 2017

5

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25 August 2017

741-753

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HIV-1 neutralization: mechanisms and relevance to vaccine design

25 August 2017

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Toward an antibody-based HIV-1 vaccine

21 January 2018

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A proposal for the nomenclature of antigenic sites in peptides and proteins

21 January 2018

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What is a B-cell epitope?

21 January 2018

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Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab

21 January 2018

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Structural and functional approaches to the study of protein antigenicity

21 January 2018

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Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools

21 January 2018

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Immune epitope database analysis resource (IEDB-AR).

21 January 2018

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Structure-activity relationships in peptide-antibody complexes: implications for epitope prediction and development of synthetic peptide vaccines.

21 January 2018

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Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies

21 January 2018

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Antigenic implications of human immunodeficiency virus type 1 envelope quaternary structure: oligomer-specific and -sensitive monoclonal antibodies

21 January 2018

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Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles

21 January 2018

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Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS technology

21 January 2018

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Evidence of viral capsid dynamics using limited proteolysis and mass spectrometry

21 January 2018

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Neutralizing epitopes of type O foot-and-mouth disease virus. II. Mapping three conformational sites with synthetic peptide reagents

21 January 2018

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Protection of cattle against foot-and-mouth disease by a synthetic peptide.

21 January 2018

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Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolate

21 January 2018

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Mapping epitopes on the insulin molecule using monoclonal antibodies

21 January 2018

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The Remarkable Flexibility of the Human Antibody Repertoire; Isolation of Over One Thousand Different Antibodies to a Single Protein, BLyS

21 January 2018

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Intrinsic and extrinsic factors in protein antigenic structure

21 January 2018

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Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies.

21 January 2018

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The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design

21 January 2018

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Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

21 January 2018

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Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies

21 January 2018

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Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals

21 January 2018

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Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

21 January 2018

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Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors

21 January 2018

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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

21 January 2018

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

21 January 2018

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Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

21 January 2018

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Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.

21 January 2018

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The antigenic structure of the HIV gp120 envelope glycoprotein

21 January 2018

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Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legs

21 January 2018

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Molecular architecture of native HIV-1 gp120 trimers

21 January 2018

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Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility

21 January 2018

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Challenges for structure-based HIV vaccine design

21 January 2018

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

21 January 2018

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Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors

21 January 2018

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Broad HIV-1 neutralization mediated by CD4-binding site antibodies

21 January 2018

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

21 January 2018

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Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

21 January 2018

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Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.

21 January 2018

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Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop

21 January 2018

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Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

21 January 2018

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Antigenic conservation and immunogenicity of the HIV coreceptor binding site

21 January 2018

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Structure of a V3-containing HIV-1 gp120 core

21 January 2018

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Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein

21 January 2018

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Identifying epitopes of HIV-1 that induce protective antibodies

21 January 2018

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Differential role of V3-specific antibodies in neutralization assays involving primary and laboratory-adapted isolates of HIV type 1.

21 January 2018

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Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.

21 January 2018

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Cross-reactivity of monoclonal antibodies to a chimeric V3 peptide of HIV-1 with peptide analogues studied by biosensor technology and ELISA.

21 January 2018

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Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization

21 January 2018

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The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

21 January 2018

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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

21 January 2018

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The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring

21 January 2018

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Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

21 January 2018

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Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

21 January 2018

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An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10

21 January 2018

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Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

21 January 2018

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Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

21 January 2018

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The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes

21 January 2018

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A new paradigm in molecular recognition? Specific antibody binding to membrane-inserted HIV-1 epitopes.

21 January 2018

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A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

21 January 2018

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The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.

21 January 2018

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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

21 January 2018

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Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region

21 January 2018

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Role of HIV membrane in neutralization by two broadly neutralizing antibodies

21 January 2018

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Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

21 January 2018

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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane

21 January 2018

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Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding

21 January 2018

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The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

21 January 2018

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Alternative conformations of HIV-1 V3 loops mimic beta hairpins in chemokines, suggesting a mechanism for coreceptor selectivity

21 January 2018

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Antibodies that are cross-reactive for human immunodeficiency virus type 1 clade a and clade B v3 domains are common in patient sera from Cameroon, but their neutralization activity is usually restricted by epitope masking

21 January 2018

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The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection

21 January 2018

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Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity

21 January 2018

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Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis

21 January 2018

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Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1.

21 January 2018

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Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes

21 January 2018

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Mimicking the structure of the V3 epitope bound to HIV-1 neutralizing antibodies

21 January 2018

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Stabilization of the biologically active conformation of the principal neutralizing determinant of HIV-1(IIIB) containing a cis-proline surrogate: 1H NMR and molecular modeling study.

21 January 2018

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Antibody-antigen interactions: new structures and new conformational changes

21 January 2018

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Correlation between segmental mobility and the location of antigenic determinants in proteins

21 January 2018

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The atomic mobility component of protein antigenicity

21 January 2018

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Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

21 January 2018

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Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus

21 January 2018

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Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

21 January 2018

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Antibody multispecificity mediated by conformational diversity

21 January 2018

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Flexibility and molecular recognition in the immune system.

21 January 2018

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A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.

21 January 2018

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Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody

21 January 2018

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Enhancement of alpha -helicity in the HIV-1 inhibitory peptide DP178 leads to an increased affinity for human monoclonal antibody 2F5 but does not elicit neutralizing responses in vitro. Implications for vaccine design

21 January 2018

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Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein

21 January 2018

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Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles

21 January 2018

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Current status of short synthetic peptides as vaccines

21 January 2018

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Polyreactivity of antibody molecules

21 January 2018

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Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies

21 January 2018

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Conformational changes associated with protein-protein interactions

21 January 2018

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Reductionism and the search for structure-function relationships in antibody molecules

21 January 2018

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Antibodies, viruses and vaccines

21 January 2018

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Reverse vaccinology, a genome-based approach to vaccine development

21 January 2018

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Genome-based approaches to develop vaccines against bacterial pathogens

21 January 2018

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Pathogen proteins eliciting antibodies do not share epitopes with host proteins: a bioinformatics approach

21 January 2018

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Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism

21 January 2018

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The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.

21 January 2018

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Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure-function relationships in immunology

21 January 2018

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Benchmarking B-cell epitope prediction for the design of peptide-based vaccines: problems and prospects

21 January 2018

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Humoral immunity to HIV-1: neutralisation and antibody effector functions

21 January 2018

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Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?

21 January 2018

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Comparing antigenicity and immunogenicity of engineered gp120.

21 January 2018

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Human immunodeficiency virus-like particles with consensus envelopes elicited broader cell-mediated peripheral and mucosal immune responses than polyvalent and monovalent Env vaccines

21 January 2018

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Specificities of broadly neutralizing anti-HIV-1 sera

21 January 2018

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Formaldehyde-treated, heat-inactivated virions with increased human immunodeficiency virus type 1 env can be used to induce high-titer neutralizing antibody responses

21 January 2018

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A multistep procedure for the chemical inactivation of human immunodeficiency virus for use as an experimental vaccine

21 January 2018

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Inactivation of viruses by aziridines

21 January 2018

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Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins

21 January 2018

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Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins

21 January 2018

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Inactivation of retroviruses with preservation of structural integrity by targeting the hydrophobic domain of the viral envelope

21 January 2018

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Virus-like particles: designing an effective AIDS vaccine

21 January 2018

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Virus-like particles as HIV-1 vaccines

21 January 2018

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21 January 2018

Spying on HIV with SPR.

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Surface plasmon resonance for vaccine design and efficacy studies: recent applications and future trends.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JMR.1116

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25 August 2017

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PubMed ID

21812050