A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies (Q27655865)

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English	A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies	scientific article

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scholarly article

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A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies (English)

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1 reference

based on heuristic

inferred from title

Ian Andrew Wilson

9

object named as

Ian A Wilson

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Dennis R. Burton

7

object named as

Dennis R Burton

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author name string

Robert Pejchal

1

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Johannes S Gach

2

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Florence M Brunel

3

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Rosa M Cardoso

4

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Robyn L Stanfield

5

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Philip E Dawson

6

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Michael B Zwick

8

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publication date

September 2009

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Journal of Virology

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83

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8451-62

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17

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Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane

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20 March 2017

Structure of Antibody F425-B4e8 in Complex with a V3 Peptide Reveals a New Binding Mode for HIV-1 Neutralization

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

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20 March 2017

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

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20 March 2017

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D

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20 March 2017

Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion

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Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

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A monomeric 3(10)-helix is formed in water by a 13-residue peptide representing the neutralizing determinant of HIV-1 on gp41

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20 March 2017

The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

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20 March 2017

Membrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusion

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20 March 2017

Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs

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20 March 2017

Core structure of gp41 from the HIV envelope glycoprotein

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20 March 2017

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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Structure of myohemerythrin in the azidomet state at 1.7/1.3 A resolution

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20 March 2017

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

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20 March 2017

Standard conformations for the canonical structures of immunoglobulins

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20 March 2017

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

1 reference

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7 April 2017

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

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7 April 2017

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

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7 April 2017

Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

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7 April 2017

Amino acid preferences for specific locations at the ends of alpha helices

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7 April 2017

Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals

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29 September 2017

Challenges in the development of an HIV-1 vaccine

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29 September 2017

Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

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29 September 2017

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29 September 2017

The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design

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29 September 2017

4E10-resistant variants in a human immunodeficiency virus type 1 subtype C-infected individual with an anti-membrane-proximal external region-neutralizing antibody response

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29 September 2017

Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis

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29 September 2017

The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes

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29 September 2017

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10

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29 September 2017

Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy

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29 September 2017

Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma

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29 September 2017

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

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29 September 2017

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29 September 2017

Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.

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29 September 2017

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29 September 2017

The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

Fine definition of the epitope on the gp41 glycoprotein of human immunodeficiency virus type 1 for the neutralizing monoclonal antibody 2F5.

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29 September 2017

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

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29 September 2017

Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro

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29 September 2017

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29 September 2017

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29 September 2017

A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.

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29 September 2017

Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys.

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29 September 2017

Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity

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29 September 2017

Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex

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29 September 2017

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29 September 2017

Protein-peptide interactions

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29 September 2017

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

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29 September 2017

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29 September 2017

Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer

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29 September 2017

Helix signals in proteins

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The molecular surface package

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2 June 2018

Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity

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27 November 2018

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

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27 November 2018

The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring

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27 November 2018

Characterization of molecular features, antigen-binding, and in vitro properties of IgG and IgM variants of 4E10, an anti-HIV type 1 neutralizing monoclonal antibody.

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27 November 2018

Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection

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27 November 2018

HIV vaccine research: the way forward

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base

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https://pubmed.ncbi.nlm.nih.gov/19515770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/JVI.00685-09

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