Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity (Q27658138)

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object named as

Zane Kraft

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author name string

Hengyu Xu

1

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Likai Song

2

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Mikyung Kim

3

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Margaret A Holmes

4

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George Sellhorn

6

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Ellis L Reinherz

7

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Roland K Strong

HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane

9

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publication date

January 2010

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published in

Journal of Virology

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volume

84

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issue

2

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page(s)

1076-88

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cites work

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The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes

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Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.

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