Interference with p53 functions in human viral infections, a target for novel antiviral strategies? (Q37897197)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21726011%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

review article

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title

Interference with p53 functions in human viral infections, a target for novel antiviral strategies? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21726011%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21726011%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Claudio R Santos

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21726011%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

publication date

1 July 2011

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Reviews in Medical Virology

6 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21726011%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

21

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6 February 2020

page(s)

285-300

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6 February 2020

issue

5

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Coping with stress: multiple ways to activate p53.

6 February 2020

cites work

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p53 in health and disease

21 January 2018

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Structural biology of the tumor suppressor p53.

21 January 2018

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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Tied up in loops: positive and negative autoregulation of p53.

21 January 2018

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p53-dependent cell cycle control: response to genotoxic stress

21 January 2018

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Dissecting p53-dependent apoptosis.

21 January 2018

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

21 January 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

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Regulation of the G2/M transition by p53.

21 January 2018

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Decision making by p53: life, death and cancer

21 January 2018

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Transcriptional regulation by p53: one protein, many possibilities

21 January 2018

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p53 transcriptional activation domain: a molecular chameleon?

21 January 2018

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The tumor suppressor p53: cancer and aging

21 January 2018

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Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer

21 January 2018

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p53: guardian of the genome and policeman of the oncogenes.

21 January 2018

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Posttranslational modification of p53: cooperative integrators of function

21 January 2018

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Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

21 January 2018

1 reference

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

21 January 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

The regulation of the p53-mediated stress response by MDM2 and MDM4.

21 January 2018

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p53 ubiquitination: Mdm2 and beyond

21 January 2018

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p53-Mdm2--the affair that never ends

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

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Hypophosphorylation of Mdm2 augments p53 stability

21 January 2018

1 reference

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

21 January 2018

1 reference

Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

21 January 2018

1 reference

p53 inhibits JC virus DNA replication in vivo and interacts with JC virus large T-antigen

21 January 2018

1 reference

JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?

21 January 2018

1 reference

E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.

21 January 2018

1 reference

Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.

21 January 2018

1 reference

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

21 January 2018

1 reference

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

1 reference

Heterochromatin silencing of p53 target genes by a small viral protein

21 January 2018

1 reference

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

21 January 2018

1 reference

Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities

21 January 2018

1 reference

Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.

21 January 2018

1 reference

Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency

21 January 2018

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The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanisms

21 January 2018

1 reference

Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion

21 January 2018

1 reference

Involvement of human herpesvirus-6 variant B in classic Hodgkin's lymphoma via DR7 oncoprotein.

21 January 2018

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A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.

21 January 2018

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Restriction of human herpesvirus 6B replication by p53.

21 January 2018

1 reference

Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma

21 January 2018

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The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.

21 January 2018

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Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.

21 January 2018

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Transcriptional repression of the human p53 gene by hepatitis B viral X protein

21 January 2018

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Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

21 January 2018

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Reactivation of p53 in cells expressing hepatitis B virus X-protein involves p53 phosphorylation and a reduction of Hdm2.

21 January 2018

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Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival

21 January 2018

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HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

21 January 2018

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NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner

21 January 2018

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p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat

21 January 2018

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Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription

21 January 2018

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The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis.

21 January 2018

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Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity

21 January 2018

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Influenza A virus induces p53 accumulation in a biphasic pattern

21 January 2018

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The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism

21 January 2018

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

21 January 2018

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Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner

21 January 2018

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Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response

21 January 2018

1 reference

Vaccinia virus gene B1R encodes a 34-kDa serine/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions

21 January 2018

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Infection with vaccinia virus alters regulation of cell cycle progression

21 January 2018

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Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling

21 January 2018

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The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

21 January 2018

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p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

21 January 2018

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Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway

21 January 2018

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c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

21 January 2018

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Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication.

21 January 2018

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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex

21 January 2018

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Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.

21 January 2018

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Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases

21 January 2018

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Human herpesvirus 6B induces phosphorylation of p53 in its regulatory domain by a CK2- and p38-independent pathway

21 January 2018

1 reference

Hepatitis C Virus Impairs p53 via Persistent Overexpression of 3 -Hydroxysterol 24-Reductase

21 January 2018

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Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis.

21 January 2018

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HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.

21 January 2018

1 reference

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

1 reference

The role of the E6-p53 interaction in the molecular pathogenesis of HPV.

21 January 2018

1 reference

Cell-specific modulation of papovavirus replication by tumor suppressor protein p53

21 January 2018

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P53 represses human papillomavirus type 16 DNA replication via the viral E2 protein

21 January 2018

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

21 January 2018

1 reference

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

21 January 2018

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Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53.

21 January 2018

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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.

21 January 2018

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EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors

21 January 2018

1 reference

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway

21 January 2018

1 reference

Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation

21 January 2018

1 reference

Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination

21 January 2018

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Potential role for p53 in the permissive life cycle of human cytomegalovirus

21 January 2018

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Cytomegalovirus inhibits p53 nuclear localization signal function

21 January 2018

1 reference

Mechanisms for human cytomegalovirus-induced cytoplasmic p53 sequestration in endothelial cells.

21 January 2018

1 reference

Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence

21 January 2018

1 reference

Inhibition of cell division by the human cytomegalovirus IE86 protein: role of the p53 pathway or cyclin-dependent kinase 1/cyclin B1.

21 January 2018

1 reference

Influenza A virus infection of mice induces nuclear accumulation of the tumorsuppressor protein p53 in the lung

21 January 2018

1 reference

Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication

21 January 2018

1 reference

Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling

21 January 2018

1 reference

Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses

21 January 2018

1 reference

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells.

21 January 2018

1 reference

The interferon response circuit: induction and suppression by pathogenic viruses

21 January 2018

1 reference

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.

21 January 2018

1 reference

Down-regulation of p53 by double-stranded RNA modulates the antiviral response

21 January 2018

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

21 January 2018

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Resistance to viral infection of super p53 mice.

21 January 2018

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Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

21 January 2018

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The tumor suppressor p53: from structures to drug discovery

21 January 2018

1 reference

21 January 2018

p53-based cancer therapy

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Stage-specific sensitivity to p53 restoration during lung cancer progression.

21 January 2018

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Selective activation of p53-mediated tumour suppression in high-grade tumours

21 January 2018

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

21 January 2018

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Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

21 January 2018

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p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas.

21 January 2018

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Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.

21 January 2018

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Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells

21 January 2018

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MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival

21 January 2018

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A stapled p53 helix overcomes HDMX-mediated suppression of p53.

21 January 2018

1 reference

Small-molecule inhibitors of the PI3K signaling network

21 January 2018

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