The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism (Q40508316)

21 September 2017

The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism (English)

1 reference

21 September 2017

vaccinia virus

1 reference

Sandra Blanco

3

0 references

Francisco M Vega

object named as

Francisco M Vega

2

0 references

Pedro A. Lazo

object named as

Pedro A Lazo

5

0 references

author name string

Cláudio R Santos

1

1 reference

PubMed ID

15464845

21 September 2017

Ramiro Barcia

4

1 reference

PubMed ID

15464845

21 September 2017

language of work or name

English

0 references

publication date

1 October 2004

1 reference

21 September 2017

1 reference

21 September 2017

328

1 reference

21 September 2017

2

1 reference

21 September 2017

254-265

1 reference

Stress signals utilize multiple pathways to stabilize p53

21 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Vaccinia virus gene B1R encodes a 34-kDa serine/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Phosphorylation of ribosomal proteins by the vaccinia virus B1R protein kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Members of a novel family of mammalian protein kinases complement the DNA-negative phenotype of a vaccinia virus ts mutant defective in the B1 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

The ubiquitin ligase COP1 is a critical negative regulator of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Expression of vaccinia E3L and K3L genes by a novel recombinant canarypox HIV vaccine vector enhances HIV-1 pseudovirion production and inhibits apoptosis in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Cellular gene expression survey of vaccinia virus infection of human HeLa cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Microarray analysis reveals characteristic changes of host cell gene expression in response to attenuated modified vaccinia virus Ankara infection of human HeLa cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Regulation of viral intermediate gene expression by the vaccinia virus B1 protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

p53, the cellular gatekeeper for growth and division

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Acetylation of p53 inhibits its ubiquitination by Mdm2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

p53 and apoptosis: it's not just in the nucleus anymore

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

The protein kinase complement of the human genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Regulation of vaccinia virus transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Effect of phosphorylation on tetramerization of the tumor suppressor protein p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Molecular mechanism of the interaction between MDM2 and p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

p53-dependent apoptosis pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

The RB and p53 pathways in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

DNA damage induces phosphorylation of the amino terminus of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

The role of the E6-p53 interaction in the molecular pathogenesis of HPV.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Live or let die: the cell's response to p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Infection with vaccinia virus alters regulation of cell cycle progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Inhibition of p53 degradation by Mdm2 acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Vaccinia virus infection disarms the mitochondrion-mediated pathway of the apoptotic cascade by modulating the permeability transition pore

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Vaccinia virus gene H5R encodes a protein that is phosphorylated by the multisubstrate vaccinia virus B1R protein kinase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

inferred from DOI database lookup

7 January 2021

based on heuristic

The vaccinia virus B1R gene product is a serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

inferred from DOI database lookup

7 January 2021

based on heuristic

Vaccinia virus B1 kinase: phenotypic analysis of temperature-sensitive mutants and enzymatic characterization of recombinant proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2004.08.013

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VIROL.2004.08.013

1 reference

21 September 2017

1 reference

PubMed ID

15464845