Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy. (Q30831001)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

review article

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title

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Klas G Wiman

series ordinal

1

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26 June 2017

1 January 2007

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

Advances in Cancer Research

28 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

97

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

page(s)

321-338

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

28 December 2019

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p53-dependent cell death/apoptosis is required for a productive adenovirus infection

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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Allosteric activation of latent p53 tetramers

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Regulation of the specific DNA binding function of p53

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Small peptides activate the latent sequence-specific DNA binding function of p53.

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Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

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7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

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7 January 2021

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

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7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

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7 January 2021

Rearrangement of the p53 gene in human osteogenic sarcomas

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Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay

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Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

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7 January 2021

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7 January 2021

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7 January 2021

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

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7 January 2021

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

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7 January 2021

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

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7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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7 January 2021

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7 January 2021

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

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7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

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7 January 2021

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

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7 January 2021

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

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7 January 2021

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7 January 2021

Inactivation of p53 Gene Expression by an Insertion of Moloney Murine Leukemia Virus-Like DNA Sequences

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7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17419952%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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