Enhanced T cell receptor gene therapy for cancer (Q37702226)

22 August 2017

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title

Enhanced T cell receptor gene therapy for cancer (English)

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22 August 2017

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Elisa Kieback

1

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22 August 2017

Wolfgang Uckert

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

1 May 2010

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Expert Opinion on Biological Therapy

22 August 2017

published in

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22 August 2017

volume

10

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22 August 2017

issue

5

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22 August 2017

page(s)

749-762

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Transfer of specificity by murine alpha and beta T-cell receptor genes

22 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells

21 January 2018

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Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells

21 January 2018

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Requirements for effective antitumor responses of TCR transduced T cells

21 January 2018

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21 January 2018

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21 January 2018

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Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding

21 January 2018

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CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

21 January 2018

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Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain

21 January 2018

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Redirecting T lymphocyte specificity by T cell receptor gene transfer--a new era for immunotherapy

21 January 2018

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TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.

21 January 2018

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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

21 January 2018

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Generation of tumor-specific, HLA class I-restricted human Th1 and Tc1 cells by cell engineering with tumor peptide-specific T-cell receptor genes.

21 January 2018

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T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapy

21 January 2018

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Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins.

21 January 2018

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Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins improves titer and selectivity

21 January 2018

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Targeted cell entry of lentiviral vectors

21 January 2018

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Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.

21 January 2018

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Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system

21 January 2018

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Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

21 January 2018

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High-resolution genome-wide mapping of transposon integration in mammals

21 January 2018

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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712591003689998

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

21 January 2018

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A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes

21 January 2018

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Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy

21 January 2018

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

21 January 2018

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Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette

21 January 2018

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Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes

21 January 2018

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Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression

21 January 2018

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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

21 January 2018

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Facilitating matched pairing and expression of TCR chains introduced into human T cells

21 January 2018

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Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

21 January 2018

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Stable, soluble T-cell receptor molecules for crystallization and therapeutics

21 January 2018

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Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

21 January 2018

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Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer

21 January 2018

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Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function.

21 January 2018

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Therapeutic potential of a tumor-specific, MHC-unrestricted T-cell receptor expressed on effector cells of the innate and the adaptive immune system through bone marrow transduction and immune reconstitution.

21 January 2018

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Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity

21 January 2018

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Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes

21 January 2018

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Display, engineering, and applications of antigen-specific T cell receptors

21 January 2018

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In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 January 2018

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Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

21 January 2018

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High affinity T cell receptors from yeast display libraries block T cell activation by superantigens.

21 January 2018

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Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.

21 January 2018

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Directed evolution of human T-cell receptors with picomolar affinities by phage display.

21 January 2018

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

21 January 2018

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Changing T cell specificity by retroviral T cell receptor display

21 January 2018

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Engineering higher affinity T cell receptors using a T cell display system

21 January 2018

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Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.

21 January 2018

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Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells

21 January 2018

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

21 January 2018

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Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: reagents for tumor immunotherapy

21 January 2018

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Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells

21 January 2018

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Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies

21 January 2018

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Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity

21 January 2018

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Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8.

21 January 2018

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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

21 January 2018

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Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.

21 January 2018

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A T-cell receptor associated with naturally occurring human tumor immunity

21 January 2018

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Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity

21 January 2018

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Antigen choice in adoptive T-cell therapy of cancer

21 January 2018

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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

21 January 2018

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Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells

21 January 2018

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Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

21 January 2018

1 reference

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Induction of peripheral tolerance in dual TCR T cells: an evidence for non-dominant signaling by one TCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors

21 January 2018

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Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.

21 January 2018

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Antitumor activity of dual-specific T cells and influenza virus

21 January 2018

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Preclinical development of T cell receptor gene therapy

21 January 2018

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Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

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Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells

21 January 2018

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Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

21 January 2018

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Progress and prospects: gene therapy for inherited immunodeficiencies

21 January 2018

1 reference

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Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur in gene groups with specific molecular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Resistance of mature T cells to oncogene transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft

21 January 2018

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HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia

21 January 2018

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T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients

21 January 2018

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Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation

21 January 2018

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Tumor cells escape suicide gene therapy by genetic and epigenetic instability

21 January 2018

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Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy

21 January 2018

1 reference

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Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies

21 January 2018

1 reference

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The CD20/alphaCD20 'suicide' system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

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Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Kinetics of cell death in T lymphocytes genetically modified with two novel suicide fusion genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

An inducible caspase 9 safety switch for T-cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712591003689998

10.1517/14712591003689998

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference