Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice (Q37701053)

22 August 2017

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice (English)

1 reference

22 August 2017

0 references

1 reference

1

1 reference

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1 June 2020

Salvatore Novello

3

1 reference

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1 June 2020

Ludovico Arcuri

4

1 reference

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1 June 2020

Derya R Shimshek

11

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1 June 2020

Luigi Bubacco

13

1 reference

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1 June 2020

Michele Morari

15

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1 June 2020

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Daniela Mercatelli

2

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1 June 2020

Alberto Brugnoli

5

1 reference

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1 June 2020

Fabrizio Vincenzi

6

1 reference

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1 June 2020

Isabella Russo

7

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1 June 2020

Giulia Berti

8

1 reference

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1 June 2020

Omar S Mabrouk

9

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1 June 2020

Robert T Kennedy

10

1 reference

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1 June 2020

Katia Varani

12

1 reference

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1 June 2020

Elisa Greggio

14

1 reference

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1 June 2020

language of work or name

1 reference

14 March 2017

1 reference

Acta Neuropathologica Communications

22 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28292328%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

5

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1 June 2020

page(s)

22

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1 June 2020

issue

1

1 reference

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https://scigraph.springernature.com/pub.10.1186/s40478-017-0426-8

1 June 2020

exact match

0 references

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G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.

23 August 2017

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Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein

23 August 2017

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

23 August 2017

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LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function

23 August 2017

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Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).

23 August 2017

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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

23 August 2017

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Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

23 August 2017

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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

23 August 2017

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Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

23 August 2017

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Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

23 August 2017

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Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease

23 August 2017

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Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

23 August 2017

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Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats

23 August 2017

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Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

23 August 2017

1 reference

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LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status

23 August 2017

1 reference

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Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo

23 August 2017

1 reference

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LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

23 August 2017

1 reference

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LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

23 August 2017

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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

23 August 2017

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Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner

23 August 2017

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The genetics of Parkinson's disease: progress and therapeutic implications

23 August 2017

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Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease

23 August 2017

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(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

23 August 2017

1 reference

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In vivo neurochemical monitoring using benzoyl chloride derivatization and liquid chromatography-mass spectrometry

23 August 2017

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

23 August 2017

1 reference

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Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

23 August 2017

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

23 August 2017

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VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease

23 August 2017

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The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis

23 August 2017

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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

23 August 2017

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

23 August 2017

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Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine

23 August 2017

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LRRK2 and Parkinson disease

23 August 2017

1 reference

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LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

23 August 2017

1 reference

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

23 August 2017

1 reference

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

23 August 2017

1 reference

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

23 August 2017

1 reference

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Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

23 August 2017

1 reference

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

23 August 2017

1 reference

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Nicotinic receptor activation increases [3H]dopamine uptake and cell surface expression of dopamine transporters in rat prefrontal cortex

23 August 2017

1 reference

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Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations

23 August 2017

1 reference

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

23 August 2017

1 reference

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Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.

23 August 2017

1 reference

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Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine

23 August 2017

1 reference

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Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration

23 August 2017

1 reference

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Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

23 August 2017

1 reference

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

23 August 2017

1 reference

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LRRK2 in Parkinson's disease: protein domains and functional insights

23 August 2017

1 reference

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Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

23 August 2017

1 reference

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

23 August 2017

1 reference

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Dopamine covalently modifies and functionally inactivates parkin

23 August 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

23 August 2017

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

23 August 2017

1 reference

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Intraneuronal dopamine-quinone synthesis: A review

23 August 2017

1 reference

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3,4-dihydroxyphenylacetaldehyde: a potential target for neuroprotective therapy in Parkinson's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

alpha-Synuclein is phosphorylated in synucleinopathy lesions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

23 August 2017

1 reference

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Dopamine transporters and neuronal injury

23 August 2017

1 reference

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Cytotoxic and genotoxic potential of dopamine

23 August 2017

1 reference

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Global spatial sampling with isotropic virtual planes: estimators of length density and total length in thick, arbitrarily orientated sections

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

LRRK2 Pathways Leading to Neurodegeneration

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

LRRK2 pathobiology in Parkinson's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Protein phosphorylation in neurodegeneration: friend or foe?

6 September 2017

1 reference

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Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

6 September 2017

1 reference

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Motor and nonmotor heterogeneity of LRRK2-related and idiopathic Parkinson's disease

6 September 2017

1 reference

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The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson's disease: a behavioral and neurochemical study in reserpinized mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Analysis of VMAT2 binding after methamphetamine or MPTP treatment: disparity between homogenates and vesicle preparations.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Immunochemical localization of vesicular monoamine transporter 2 (VMAT2) in mouse brain.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

(R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Pharmacological and genetic evidence for pre- and postsynaptic D2 receptor involvement in motor responses to nociceptin/orphanin FQ receptor ligands

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Amantadine attenuates levodopa-induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levels

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: implications for Huntington's disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Accumulation of phosphorylated alpha-synuclein in aging human brain.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5351259

Neuroprotection for Parkinson's disease: a call for clinically driven experimental design

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28292328

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An endogenous dopaminergic neurotoxin: implication for Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28292328

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S40478-017-0426-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28292328%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28292328%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference