LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function (Q36581417)

15 August 2017

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function (English)

1 reference

15 August 2017

Anna-Kristin Kaufmann

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Natalie Connor-Robson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Katherine R Brimblecombe

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

David M Bannerman

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

J Paul Bolam

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Peter J Magill

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Stephanie J Cragg

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Paul D. Dodson

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Richard Wade-Martins

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Max Sloan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Javier Alegre-Abarrategui

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Dawid Potgieter

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Richard Exley

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Thierry Deltheil

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sarah Threlfell

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Rebecca Wallings

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Milena Cioroch

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

6 January 2016

1 reference

15 August 2017

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

951-963

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

10 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4754049/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

1 reference

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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

9 September 2017

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Cognitive profile of LRRK2-related Parkinson's disease

9 September 2017

1 reference

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Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

9 September 2017

1 reference

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Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats

9 September 2017

1 reference

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Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

9 September 2017

1 reference

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LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis

9 September 2017

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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

9 September 2017

1 reference

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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

9 September 2017

1 reference

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Measuring motor coordination in mice

9 September 2017

1 reference

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Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse

9 September 2017

1 reference

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Retake the center stage--new development of rat genetics

9 September 2017

1 reference

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(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

9 September 2017

1 reference

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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

9 September 2017

1 reference

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Cognitive dysfunction in Tunisian LRRK2 associated Parkinson's disease

9 September 2017

1 reference

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Dopamine release in the basal ganglia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

9 September 2017

1 reference

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

9 September 2017

1 reference

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Clinical features of LRRK2 parkinsonism

9 September 2017

1 reference

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

9 September 2017

1 reference

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R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

9 September 2017

1 reference

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

9 September 2017

1 reference

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

9 September 2017

1 reference

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

9 September 2017

1 reference

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

9 September 2017

1 reference

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A common LRRK2 mutation in idiopathic Parkinson's disease

9 September 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

9 September 2017

1 reference

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9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Detection of bursts and pauses in spike trains

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Influence of phasic and tonic dopamine release on receptor activation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Variable dopamine release probability and short-term plasticity between functional domains of the primate striatum.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Comparison of serotonin and dopamine release in substantia nigra and ventral tegmental area: region and species differences.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Cognitive and behavioral symptoms in Parkinson's disease patients with the G2019S and R1441G mutations of the LRRK2 gene.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Cognitive dysfunction in Parkinson's disease related to the R1441G mutation in LRRK2.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from southern Italy.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

T-maze alternation in the rodent.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Nicotine amplifies reward-related dopamine signals in striatum

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4754049

Quantitative analysis of gait in Parkinson patients: increased variability of stride length

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26744332

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Symptoms of autonomic failure in Parkinson's disease: prevalence and impact on daily life

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26744332

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDV628

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26744332%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference