CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis. (Q37679999)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24614102%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis (English)

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10 March 2020

5

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10 March 2020

author name string

Yuanzhi Lu

1

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10 March 2020

Yongsheng Wu

2

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10 March 2020

Xiaoling Feng

3

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10 March 2020

Rulong Shen

4

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10 March 2020

Mohammad Fallahi

6

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10 March 2020

Weimin Li

7

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10 March 2020

Chunying Yang

8

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10 March 2020

William Hankey

9

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10 March 2020

Weiqiang Zhao

10

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10 March 2020

Ramesh K Ganju

11

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10 March 2020

Ming O Li

12

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10 March 2020

John L Cleveland

13

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10 March 2020

Xianghong Zou

14

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10 March 2020

language of work or name

English

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publication date

10 March 2014

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Journal of Clinical Investigation

10 March 2020

published in

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10 March 2020

volume

124

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10 March 2020

page(s)

1672-1684

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10 March 2020

issue

4

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Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.

10 March 2020

cites work

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Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1

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The RAG2 C terminus suppresses genomic instability and lymphomagenesis

23 August 2017

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The ups and downs of Myc biology

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Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex

23 August 2017

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Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation

23 August 2017

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Mechanisms promoting translocations in editing and switching peripheral B cells

23 August 2017

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Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

23 August 2017

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Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53.

23 August 2017

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Cell cycle, CDKs and cancer: a changing paradigm

23 August 2017

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Reflecting on 25 years with MYC.

23 August 2017

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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

23 August 2017

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Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

23 August 2017

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Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons

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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

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23 August 2017

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

23 August 2017

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Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

23 August 2017

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Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes

23 August 2017

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23 August 2017

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Identification of CDK4 as a target of c-MYC.

23 August 2017

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

23 August 2017

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

23 August 2017

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

23 August 2017

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

23 August 2017

1 reference

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RAG-1-deficient mice have no mature B and T lymphocytes

23 August 2017

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Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

23 August 2017

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Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.

23 August 2017

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FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.

6 September 2017

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The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers

6 September 2017

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A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

6 September 2017

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CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

14 September 2017

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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

14 September 2017

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

14 September 2017

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Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.

28 September 2017

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Overall Cdk activity modulates the DNA damage response in mammalian cells

28 September 2017

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FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

25 June 2018

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Transformed diffuse large B-cell lymphomas with gains of the discontinuous 12q12-14 amplicon display concurrent deregulation of CDK2, CDK4 and GADD153 genes.

25 June 2018

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Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

25 June 2018

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Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas.

1 September 2018

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AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice

1 September 2018

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A mouse model for cyclin E-dependent genetic instability and tumorigenesis

1 September 2018

1 reference

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Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

1 September 2018

1 reference

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Cyclin-dependent kinases regulate the antiproliferative function of Smads.

1 September 2018

1 reference

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

1 September 2018

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

1 September 2018

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CDK4andMDM2Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-typeINK4a/ARFLocus

3 December 2018

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

3 December 2018

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12 December 2020

RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences

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12 December 2020

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

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Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2

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12 December 2020

Identifiers

DOI

10.1172/JCI63139

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24614102%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24614102%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference