Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling (Q37400609)

20 August 2017

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title

Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling (English)

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20 August 2017

Sebastian Herzog

1

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20 August 2017

Michael Reth

series ordinal

2

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20 August 2017

Hassan Jumaa

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3

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20 August 2017

1 March 2009

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Nature Reviews Immunology

20 August 2017

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20 August 2017

9

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20 August 2017

195-205

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20 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nri2491

20 August 2017

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cites work

B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta

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Cutting edge: signaling and cell surface expression of a mu H chain in the absence of lambda 5: a paradigm revisited.

21 January 2018

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Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines

21 January 2018

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IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development.

21 January 2018

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Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

21 January 2018

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Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

21 January 2018

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Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19.

21 January 2018

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Regulating antigen-receptor gene assembly

21 January 2018

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Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins

31 March 2020

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B cell signaling and tumorigenesis

31 March 2020

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B cell development in the mouse from early progenitors to mature B cells.

31 March 2020

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The V(D)J recombination activating gene, RAG-1.

31 March 2020

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

31 March 2020

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Mechanism and regulation of human non-homologous DNA end-joining

31 March 2020

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Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow

31 March 2020

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The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire

31 March 2020

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

31 March 2020

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Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

31 March 2020

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A critical role of λ5 protein in B cell development

31 March 2020

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Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice

31 March 2020

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A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

31 March 2020

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Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components

31 March 2020

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Identification of a pre-BCR lacking surrogate light chain

31 March 2020

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VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus

31 March 2020

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Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia

31 March 2020

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Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

31 March 2020

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The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.

31 March 2020

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Pre-BCR signals and the control of Ig gene rearrangements

31 March 2020

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Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement

31 March 2020

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Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor

31 March 2020

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Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

31 March 2020

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Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering

31 March 2020

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Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment

31 March 2020

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The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling

31 March 2020

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Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells

31 March 2020

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Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta

31 March 2020

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Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor

31 March 2020

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Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

31 March 2020

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Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

31 March 2020

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Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

31 March 2020

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Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

31 March 2020

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Syk tyrosine kinase required for mouse viability and B-cell development

31 March 2020

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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

31 March 2020

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Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.

31 March 2020

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

31 March 2020

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TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways

31 March 2020

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Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma

31 March 2020

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Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase

31 March 2020

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PI3K in lymphocyte development, differentiation and activation

31 March 2020

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AKT/PKB signaling: navigating downstream

31 March 2020

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Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia

31 March 2020

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The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

31 March 2020

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Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors

31 March 2020

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Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection

31 March 2020

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The Ig-alpha ITAM is required for efficient differentiation but not proliferation of pre-B cells

31 March 2020

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Interaction of SLP adaptors with the SH2 domain of Tec family kinases

31 March 2020

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BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

31 March 2020

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Regulation of activation and recombination of the murine Igkappa locus

31 March 2020

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Foxp1 is an essential transcriptional regulator of B cell development

31 March 2020

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Helix-loop-helix proteins and lymphocyte development

31 March 2020

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A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines

31 March 2020

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Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling.

31 March 2020

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IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

31 March 2020

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An essential role for BLNK in human B cell development

31 March 2020

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SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.

31 March 2020

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Basal immunoglobulin signaling actively maintains developmental stage in immature B cells

31 March 2020

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Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

31 March 2020

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

31 March 2020

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FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

31 March 2020

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Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

31 March 2020

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

31 March 2020

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Forkhead-box transcription factors and their role in the immune system

31 March 2020

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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

31 March 2020

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

31 March 2020

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FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1.

31 March 2020

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

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A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells

31 March 2020

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

31 March 2020

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Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

31 March 2020

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V(D)J recombination and the cell cycle.

31 March 2020

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RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation

31 March 2020

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A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

31 March 2020

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

31 March 2020

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31 March 2020

Recycling the Cell Cycle

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Pocket proteins and cell cycle control

31 March 2020

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Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo

31 March 2020

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INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.

31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

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Another piece of the p27Kip1 puzzle

31 March 2020

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

31 March 2020

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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

31 March 2020

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

31 March 2020

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

31 March 2020

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

31 March 2020

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A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells

31 March 2020

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p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo.

31 March 2020

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Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

31 March 2020

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A unique function for cyclin D3 in early B cell development

31 March 2020

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FOXOs, cancer and regulation of apoptosis

31 March 2020

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Impaired receptor editing in the primary B cell repertoire of BASH-deficient mice

31 March 2020

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Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing

31 March 2020

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The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells.

31 March 2020

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Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

31 March 2020

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CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing

31 March 2020

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Choreography of Ig allelic exclusion

31 March 2020

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Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression

31 March 2020

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IL-7: a key regulator of B lymphopoiesis

31 March 2020

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Inhibition of interleukin 7 receptor signaling by antigen receptor assembly

31 March 2020

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Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling

31 March 2020

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Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen

31 March 2020

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V(D)J recombination and allelic exclusion of a TCR beta-chain minilocus occurs in the absence of a functional promoter

31 March 2020

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12 December 2020

The PI3K-PDK1 connection: more than just a road to PKB

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12 December 2020

Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression

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12 December 2020

Surrogate light chain in B cell development.

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12 December 2020

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains

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12 December 2020

Lymphoproliferative disorders in an IL-7 transgenic mouse line

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12 December 2020

Recycling the cell cycle: cyclins revisited

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12 December 2020

Identifiers

DOI

10.1038/NRI2491

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Dimensions Publication ID

20 August 2017

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