BH3-only proteins: the death-puppeteer's wires (Q37629756)

21 August 2017

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title

BH3-only proteins: the death-puppeteer's wires (English)

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21 August 2017

Fabio Ghiotto

1

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21 August 2017

Franco Fais

series ordinal

2

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21 August 2017

Silvia Bruno

series ordinal

3

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21 August 2017

publication date

1 January 2010

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21 August 2017

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21 August 2017

volume

77

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21 August 2017

issue

1

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21 August 2017

page(s)

11-21

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Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

Pushing cancer cells to commit suicide: is 072RB, the new BH3 mimetic, up to the job?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mechanical aspects of apoptosome assembly

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Viral control of mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mitochondrial membrane permeabilization in cell death

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Involvement of the bcl-2 gene in human follicular lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

BAX activation is initiated at a novel interaction site

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

A stapled BID BH3 helix directly binds and activates BAX

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Apoptosis: Stabbed in the BAX.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bcl-XL inhibits membrane permeabilization by competing with Bax.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

PUMA, a potent killer with or without p53

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through up-regulation of Bnip3L.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Human and murine granzyme B exhibit divergent substrate preferences

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transfer

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bad-deficient mice develop diffuse large B cell lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bim is a suppressor of Myc-induced mouse B cell leukemia

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Causes and consequences of microRNA dysregulation in cancer

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

BCL-2 family antagonists for cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Flow cytometric detection of the mitochondrial BCL-2 protein in normal and neoplastic human lymphoid cells

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Mechanism of mitochondrial 7A6 antigen exposure triggered by distinct apoptotic pathways: involvement of caspases.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Flow cytometric immunophenotyping including Bcl-2 detection on fine needle aspirates in the diagnosis of reactive lymphadenopathy and non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bcl-2: bax and bcl-2: Bcl-x ratios by image cytometric quantitation of immunohistochemical expression in ovarian carcinoma: correlation with prognosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Standardizing flow cytometry: a classification system of fluorescence standards used for flow cytometry

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Quantitative fluorescence cytometric analysis of Bcl-2 levels in tumor cells exhibiting a wide range of inherent Bcl-2 protein expression: correlation with Western blot analysis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Bcl-2 regulatory pathway is functional in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Three-color versus four-color multiparameter cell cycle analyses of primary acute myeloid leukemia samples

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

EGF-induced redistribution of erbB2 on breast tumor cells: flow and image cytometric energy transfer measurements

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

1 reference

7 January 2021

Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Computer program for analyzing donor photobleaching FRET image series.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Evaluation of intensity-based ratiometric FRET in image cytometry--approaches and a software solution

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Novel calibration method for flow cytometric fluorescence resonance energy transfer measurements between visible fluorescent proteins

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Long wavelength fluorophores and cell-by-cell correction for autofluorescence significantly improves the accuracy of flow cytometric energy transfer measurements on a dual-laser benchtop flow cytometer.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Two-sided fluorescence resonance energy transfer for assessing molecular interactions of up to three distinct species in confocal microscopy

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Protein detection using proximity-dependent DNA ligation assays.

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Proximity or no proximity: that is the question - but the answer is more complex

1 reference

https://api.crossref.org/works/10.1002%2FCYTO.A.20819

7 January 2021

Identifiers

DOI

10.1002/CYTO.A.20819

1 reference

21 August 2017

1 reference