2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system. (Q37614812)

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27 February 2020

title

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system (English)

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27 February 2020

6

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5

Steven A Rosenberg

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27 February 2020

author name string

Baoyu Liu

1

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27 February 2020

Shi Zhong

2

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27 February 2020

Karolina Malecek

3

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27 February 2020

Laura A Johnson

4

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27 February 2020

Michelle Krogsgaard

7

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27 February 2020

language of work or name

English

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publication date

20 October 2013

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European Journal of Immunology

27 February 2020

published in

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volume

44

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27 February 2020

issue

1

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page(s)

239-250

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T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

27 February 2020

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CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

23 August 2017

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23 August 2017

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23 August 2017

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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

23 August 2017

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23 August 2017

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

23 August 2017

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23 August 2017

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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

23 August 2017

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23 August 2017

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Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines

23 August 2017

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Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

23 August 2017

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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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6 September 2017

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28 September 2017

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25 June 2018

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25 June 2018

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A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

25 June 2018

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Kinetics of MHC-CD8 interaction at the T cell membrane.

25 June 2018

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Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) interactions.

1 September 2018

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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

1 September 2018

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

1 September 2018

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Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

1 September 2018

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Crossref

https://api.crossref.org/works/10.1002%2FEJI.201343774

Quantifying the impact of membrane microtopology on effective two-dimensional affinity

21 January 2018

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12 December 2020

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

1 reference

12 December 2020

T-cell receptor binding kinetics in T-cell development and activation

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12 December 2020

Caveats in the design of MHC class I tetramer/antigen-specific T lymphocytes dissociation assays

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12 December 2020

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

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12 December 2020

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

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12 December 2020

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

12 December 2020

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

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12 December 2020

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues

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12 December 2020

Identifiers

DOI

10.1002/EJI.201343774

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24114747%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24114747%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference