How T cells 'see' antigen (Q36045188)

11 August 2017

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title

How T cells 'see' antigen (English)

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11 August 2017

Michelle Krogsgaard

1

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PubMed ID

15716973

11 August 2017

Mark M Davis

series ordinal

2

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PubMed ID

15716973

11 August 2017

language of work or name

English

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publication date

1 March 2005

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11 August 2017

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11 August 2017

6

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3

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11 August 2017

239-245

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

11 August 2017

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7 January 2021

Ligand recognition by alpha beta T cell receptors

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7 January 2021

Molecular interactions mediating T cell antigen recognition

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7 January 2021

Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion

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7 January 2021

The kinetics of protein-protein recognition.

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7 January 2021

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

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7 January 2021

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

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7 January 2021

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor

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7 January 2021

The crystal structure of a T cell receptor in complex with peptide and MHC class II

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7 January 2021

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

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7 January 2021

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

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7 January 2021

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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7 January 2021

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

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7 January 2021

A structural basis for immunodominant human T cell receptor recognition

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7 January 2021

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

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7 January 2021

Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization

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7 January 2021

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

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7 January 2021

TCR binding to peptide-MHC stabilizes a flexible recognition interface

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7 January 2021

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

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7 January 2021

Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis

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7 January 2021

Distinct molecular mechanisms account for the specificity of two different T-cell receptors

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7 January 2021

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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7 January 2021

The immunological evolution of catalysis

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7 January 2021

Structural insights into the evolution of an antibody combining site

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7 January 2021

The interplay between binding energy and catalysis in the evolution of a catalytic antibody

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7 January 2021

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

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7 January 2021

The specificity of TCR/pMHC interaction

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7 January 2021

What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?

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7 January 2021

The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

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7 January 2021

Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

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7 January 2021

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

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7 January 2021

Control of MHC restriction by TCR Valpha CDR1 and CDR2

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7 January 2021

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

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7 January 2021

Selecting and maintaining a diverse T-cell repertoire

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7 January 2021

Recognition of multiple peptide cores by a single T cell receptor

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7 January 2021

Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

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7 January 2021

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands

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7 January 2021

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

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7 January 2021

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

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7 January 2021

T-cell-receptor affinity and thymocyte positive selection

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7 January 2021

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

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7 January 2021

Peptide antagonism and T cell receptor interactions with peptide-MHC complexes

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7 January 2021

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

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7 January 2021

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

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7 January 2021

Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

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7 January 2021

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

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7 January 2021

The minimal number of class II MHC-antigen complexes needed for T cell activation

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7 January 2021

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

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7 January 2021

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

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7 January 2021

Minimal requirements for peptide mediated activation of CD8+ CTL.

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7 January 2021

Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

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7 January 2021

Direct observation of ligand recognition by T cells.

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7 January 2021

T cell killing does not require the formation of a stable mature immunological synapse.

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7 January 2021

Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

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7 January 2021

Elaborate interactions between the immune and nervous systems

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7 January 2021

How photons start vision

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7 January 2021

Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases

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7 January 2021

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

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7 January 2021

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

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7 January 2021

Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules

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7 January 2021

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

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7 January 2021

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

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7 January 2021

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

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7 January 2021

TCRs with high affinity for foreign pMHC show self-reactivity

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7 January 2021

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

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7 January 2021

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

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7 January 2021

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

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7 January 2021

The T-cell receptor signalosome: a dynamic structure with expanding complexity

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7 January 2021

The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

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7 January 2021

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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7 January 2021

How the immune system works to protect the host from infection: a personal view

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7 January 2021

Differential clustering of CD4 and CD3zeta during T cell recognition

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7 January 2021

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

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7 January 2021

The immunological synapse balances T cell receptor signaling and degradation

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7 January 2021

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

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7 January 2021

Identifiers

DOI

10.1038/NI1173

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11 August 2017

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PubMed ID

15716973