Fast on-rates allow short dwell time ligands to activate T cells (Q33928549)

30 July 2017

Fast on-rates allow short dwell time ligands to activate T cells (English)

1 reference

30 July 2017

Christopher C Govern

1

1 reference

30 July 2017

Michelle K Paczosa

series ordinal

2

1 reference

30 July 2017

Arup K Chakraborty

series ordinal

3

1 reference

30 July 2017

Eric S Huseby

series ordinal

4

1 reference

30 July 2017

language of work or name

English

0 references

publication date

26 April 2010

1 reference

30 July 2017

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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30 July 2017

107

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30 July 2017

8724-8729

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30 July 2017

19

1 reference

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

A role for rebinding in rapid and reliable T cell responses to antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Measuring diffusion and binding kinetics by contact area FRAP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

What is the biological relevance of the specific bond properties revealed by single-molecule studies?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

The kinetic-segregation model: TCR triggering and beyond

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Kinetics of bimolecular reactions in model bilayers and biological membranes. A critical review.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Understanding specificity and sensitivity of T-cell recognition.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

The T cell receptor: critical role of the membrane environment in receptor assembly and function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Negative selection--clearing out the bad apples from the T-cell repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Alternate interactions define the binding of peptides to the MHC molecule IA(b).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Identification of self through two-dimensional chemistry and synapses.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

The immunological synapse: a molecular machine controlling T cell activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

T-cell-receptor affinity and thymocyte positive selection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Kinetic proofreading in T-cell receptor signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Models for the Specific Adhesion of Cells to Cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889346

Evidence for a differential avidity model of T cell selection in the thymus

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1000966107

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1000966107

How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1000966107

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20421471

12 December 2020

inferred from PubMed ID database lookup

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20421471

12 December 2020

inferred from PubMed ID database lookup

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20421471

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1000966107

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference