T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex (Q27675661)

1

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Samanthi Narayanan

2

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Baoyu Liu

3

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Michael E Birnbaum

4

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Andrew C Kruse

5

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Natalie A Bowerman

6

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Wei Chen

7

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Aron M Levin

8

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Janet M Connolly

9

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Cheng Zhu

10

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David M Kranz

11

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K Christopher Garcia

Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-E

12

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language of work or name

English

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publication date

23 November 2011

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published in

Immunity

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volume

35

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page(s)

681-93

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issue

5

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cites work

1 reference

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T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

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Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

20 March 2017

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Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

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How a single T cell receptor recognizes both self and foreign MHC

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How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?

20 March 2017

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A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

20 March 2017

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A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection

20 March 2017

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

20 March 2017

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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

20 March 2017

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

20 March 2017

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Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

20 March 2017

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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

20 March 2017

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Late arrival: recruiting coreceptors to the T cell receptor complex

20 March 2017

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Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

20 March 2017

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The molecular basis of TCR germline bias for MHC is surprisingly simple

20 March 2017

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TCR-MHC docking orientation: natural selection, or thymic selection?

20 March 2017

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How TCRs bind MHCs, peptides, and coreceptors

7 April 2017

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T cell receptor antagonist peptides induce positive selection

7 April 2017

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Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.

7 April 2017

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Mechanisms for T cell receptor triggering

29 September 2017

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Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

29 September 2017

1 reference

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Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling

29 September 2017

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Fast on-rates allow short dwell time ligands to activate T cells

29 September 2017

1 reference

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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

29 September 2017

1 reference

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Evidence for a functional sidedness to the alphabetaTCR.

29 September 2017

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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

29 September 2017

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Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

29 September 2017

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Structural alterations in peptide-MHC recognition by self-reactive T cell receptors

29 September 2017

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The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

29 September 2017

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Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions

29 September 2017

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The fidelity, occasional promiscuity, and versatility of T cell receptor recognition

29 September 2017

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Evolutionarily conserved amino acids that control TCR-MHC interaction

29 September 2017

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29 September 2017

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What guides MHC-restricted TCR recognition?

29 September 2017

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Isolating and engineering human antibodies using yeast surface display

29 September 2017

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Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld.

29 September 2017

1 reference

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Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions

29 September 2017

1 reference

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Deconstructing the form and function of the TCR/CD3 complex

29 September 2017

1 reference

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How the T cell receptor sees antigen--a structural view

29 September 2017

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Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

29 September 2017

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TCRs with high affinity for foreign pMHC show self-reactivity

29 September 2017

1 reference

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Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

29 September 2017

1 reference

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The immunological synapse.

29 September 2017

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An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries

29 September 2017

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Measuring two-dimensional receptor-ligand binding kinetics by micropipette

29 September 2017

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T-cell-receptor affinity and thymocyte positive selection

29 September 2017

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High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins

29 September 2017

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Ligands for the T-cell receptor: hard times for avidity models

29 September 2017

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Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes

29 September 2017

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Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

2 June 2018

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Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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How the T Cell Repertoire Becomes Peptide and MHC Specific

27 November 2018

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27 November 2018

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

27 November 2018

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Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues

27 November 2018

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MHC restriction: slip-sliding away

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A very high level of crossreactivity is an essential feature of the T-cell receptor

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Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

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The multiple mechanisms of T cell receptor cross-reactivity

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High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

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Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition

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10.1016/J.IMMUNI.2011.09.013

Identifiers

DOI

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1618313

1618313

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1 reference

1 reference