The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire (Q36184410)

12 August 2017

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title

The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire (English)

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12 August 2017

Fritz Melchers

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12 August 2017

1 July 2005

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Nature Reviews Immunology

12 August 2017

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12 August 2017

5

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12 August 2017

578-584

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12 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nri1649

12 August 2017

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cites work

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate

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Somatic generation of antibody diversity

21 January 2018

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Development of the primary antibody repertoire

21 January 2018

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Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

21 January 2018

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The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain

21 January 2018

1 reference

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface

21 January 2018

1 reference

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines

21 January 2018

1 reference

Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface

21 January 2018

1 reference

Fate of surrogate light chains in B lineage cells

21 January 2018

1 reference

The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain

21 January 2018

1 reference

A critical role of λ5 protein in B cell development

21 January 2018

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Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice

21 January 2018

1 reference

The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus

21 January 2018

1 reference

The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling

21 January 2018

1 reference

Pre-B cell-specific lambda 5 gene expression due to suppression in non pre-B cells.

21 January 2018

1 reference

Novel mechanisms control the folding and assembly of lambda5/14.1 and VpreB to produce an intact surrogate light chain

21 January 2018

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Fit for life in the immune system? Surrogate L chain tests H chains that test L chains

21 January 2018

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Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies

21 January 2018

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Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression

21 January 2018

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The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development

21 January 2018

1 reference

A transgenic marker for mouse B lymphoid precursors

21 January 2018

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Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages

21 January 2018

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EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

21 January 2018

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Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.

21 January 2018

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The helix-loop-helix gene E2A is required for B cell formation

21 January 2018

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

21 January 2018

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Failure of B-cell differentiation in mice lacking the transcription factor EBF.

21 January 2018

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Transcriptional control of early B cell development

21 January 2018

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B cell development in mice with a defective lambda 5 gene.

21 January 2018

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Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta

21 January 2018

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Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

21 January 2018

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A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

21 January 2018

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Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

21 January 2018

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Antigen receptor tail clue.

21 January 2018

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Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development

21 January 2018

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Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

21 January 2018

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Checks and balances on developing B cells.

21 January 2018

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Defective B cell development and function in Btk-deficient mice

21 January 2018

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Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia

21 January 2018

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

21 January 2018

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Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

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The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

21 January 2018

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Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice.

21 January 2018

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Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

21 January 2018

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Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate.

21 January 2018

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Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering

21 January 2018

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Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines

21 January 2018

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Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment

21 January 2018

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The variable, C(H)1, C(H)2 and C(H)3 domains of Ig heavy chain are dispensable for pre-BCR function in transgenic mice.

21 January 2018

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Analysis of the B-cell progenitor compartment at the level of single cells.

21 January 2018

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Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement

21 January 2018

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Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

21 January 2018

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Identification of a pre-BCR lacking surrogate light chain

21 January 2018

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Cutting edge: signaling and cell surface expression of a mu H chain in the absence of lambda 5: a paradigm revisited.

21 January 2018

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Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components

21 January 2018

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Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition

21 January 2018

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Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition

21 January 2018

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IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

21 January 2018

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The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

21 January 2018

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Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.

21 January 2018

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Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements

21 January 2018

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Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

21 January 2018

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Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

21 January 2018

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Mu heavy chains can associate with a pseudo-light chain complex (ψL) in human pre-B cell lines

21 January 2018

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Localization of the murine lambda 5 gene on chromosome 16

21 January 2018

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VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus

31 March 2020

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Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression

31 March 2020

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The initiation of B cell clonal expansion occurs independently of pre-B cell receptor formation

31 March 2020

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Identification of CD19(-)B220(+)c-Kit(+)Flt3/Flk-2(+)cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow

31 March 2020

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Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

31 March 2020

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IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development

31 March 2020

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B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

31 March 2020

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The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

31 March 2020

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The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation

31 March 2020

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Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors

31 March 2020

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Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1649

1 reference

PubMed ID

15999097

Dimensions Publication ID

12 August 2017

0 references

1 reference

PubMed ID

15999097