TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways (Q40594564)

21 September 2017

TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways (English)

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21 September 2017

T Kanie

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21 September 2017

A Abe

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21 September 2017

T Matsuda

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21 September 2017

Y Kuno

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21 September 2017

M Towatari

5

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21 September 2017

T Yamamoto

6

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21 September 2017

H Saito

7

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21 September 2017

N Emi

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21 September 2017

T Naoe

9

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21 September 2017

1 March 2004

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21 September 2017

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18

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3

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21 September 2017

548-555

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403266

21 September 2017

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Cellular signalling pathways: new targets in leukaemia therapy

21 January 2018

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Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine

21 January 2018

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Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells

21 January 2018

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SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling

21 January 2018

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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Syk tyrosine kinase required for mouse viability and B-cell development

21 January 2018

1 reference

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Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

21 January 2018

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Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

1 reference

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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Cytokine receptor signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Serine/threonine phosphorylation in cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway

21 January 2018

1 reference

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Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

1 reference

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes

21 January 2018

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Comparison of three in vitro assay systems used for assessing cytotoxic effect of heavy metals on cultured human keratinocytes

21 January 2018

1 reference

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Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells

21 January 2018

1 reference

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The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

21 January 2018

1 reference

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STATs: signal transducers and activators of transcription

21 January 2018

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STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

The TEL gene products: nuclear phosphoproteins with DNA binding properties

21 January 2018

1 reference

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Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

21 January 2018

1 reference

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

21 January 2018

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Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

21 January 2018

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

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Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

Interleukin 2 mediates p72 syk activation in peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

An atypical myelodysplastic syndrome with t(9;12)(q22;p12) and TEL gene rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

Vectors for expression and secretion of FLAG epitope-tagged proteins in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403266

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403266

1 reference

Dimensions Publication ID

21 September 2017

1035687093

0 references

Fatcat ID

release_o7chjkt4jnhn5lwegbmp5zqioq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o7chjkt4jnhn5lwegbmp5zqioq

24 November 2022

mapped directly with Wikidata item

1 reference