Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. (Q37196175)

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25 January 2020

title

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling (English)

1 reference

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25 January 2020

1 reference

10

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25 January 2020

Edita Aksamitiene

2

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25 January 2020

Anatoly Kiyatkin

3

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25 January 2020

Stefan Legewie

4

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25 January 2020

Jan B. Hoek

9

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25 January 2020

author name string

Nikolay Borisov

1

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25 January 2020

Jan Berkhout

5

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25 January 2020

Thomas Maiwald

6

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25 January 2020

Nikolai P Kaimachnikov

7

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25 January 2020

Jens Timmer

8

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25 January 2020

publication date

7 April 2009

1 reference

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Molecular Systems Biology

25 January 2020

published in

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volume

5

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25 January 2020

page(s)

256

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Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

25 January 2020

cites work

1 reference

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A quantitative protein interaction network for the ErbB receptors using protein microarrays

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Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity

6 September 2017

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Protein tyrosine phosphatases and signalling

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells

6 September 2017

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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

6 September 2017

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The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

6 September 2017

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The RAF proteins take centre stage

6 September 2017

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Identification of major ERK-related phosphorylation sites in Gab1.

6 September 2017

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Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

6 September 2017

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The Coherent Feedforward Loop Serves as a Sign-sensitive Delay Element in Transcription Networks

6 September 2017

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MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

6 September 2017

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Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

6 September 2017

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An integrated model of epidermal growth factor receptor trafficking and signal transduction

6 September 2017

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Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling

6 September 2017

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The "Gab" in signal transduction.

6 September 2017

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Protein tyrosine phosphatases: the quest for negative regulators of insulin action

6 September 2017

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Structural biology of insulin and IGF1 receptors: implications for drug design

6 September 2017

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6 September 2017

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6 September 2017

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Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor

6 September 2017

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The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

6 September 2017

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PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

6 September 2017

1 reference

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A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

6 September 2017

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Cell signaling by receptor tyrosine kinases

6 September 2017

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Why cytoplasmic signalling proteins should be recruited to cell membranes.

6 September 2017

1 reference

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Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

6 September 2017

1 reference

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

6 September 2017

1 reference

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

6 September 2017

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Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors

6 September 2017

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The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling

6 September 2017

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The IRS-signalling system: a network of docking proteins that mediate insulin action

6 September 2017

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Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

6 September 2017

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

6 September 2017

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YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites

6 September 2017

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Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis

6 September 2017

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Role of IRS-1-GRB-2 complexes in insulin signaling

6 September 2017

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Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

6 September 2017

1 reference

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

6 September 2017

1 reference

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

6 September 2017

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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

6 September 2017

1 reference

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Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

6 September 2017

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Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

6 September 2017

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Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor

14 September 2017

1 reference

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EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells

14 September 2017

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Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.

14 September 2017

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Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

28 September 2017

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Epidermal growth factor triggers the translocation of insulin-responsive glucose transporter (GLUT4).

28 September 2017

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Signal processing at the Ras circuit: what shapes Ras activation patterns?

28 September 2017

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Insulin potentiates EGFR activation and signaling in fibroblasts.

26 June 2018

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Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation

26 June 2018

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A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling

26 June 2018

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Molecular interpretation of ERK signal duration by immediate early gene products

26 June 2018

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Insulin induces epidermal growth factor (EGF) receptor clustering and potentiates EGF-stimulated DNA synthesis in swiss 3T3 cells: a mechanism for costimulation in mitogenic synergy

26 June 2018

1 reference

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

26 June 2018

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Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

26 June 2018

1 reference

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Untangling the signalling wires

26 June 2018

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A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity

3 September 2018

1 reference

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Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway.

3 September 2018

1 reference

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Contribution of PKC-dependent and -independent processes in temporal ERK regulation by ET-1, PDGF, and EGF in rat myometrial cells

3 September 2018

1 reference

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Epidermal growth factor and transforming growth factor alpha mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance

3 September 2018

1 reference

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Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

3 September 2018

1 reference

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Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic model

3 September 2018

1 reference

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Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase

3 September 2018

1 reference

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Mathematical simulation and analysis of cellular metabolism and regulation.

3 September 2018

1 reference

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Role of binding proteins to IRS-1 in insulin signalling.

3 September 2018

1 reference

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Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683723

SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways

3 September 2018

1 reference

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Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683723

Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMSB.2009.19

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMSB.2009.19

Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMSB.2009.19

Insulin-induced desensitization of extracellular signal-regulated kinase activation results from an inhibition of Raf activity independent of Ras activation and dissociation of the Grb2-SOS complex

21 January 2018

1 reference

12 December 2020

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

1 reference

12 December 2020

Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin

1 reference

12 December 2020

Insulin receptor what role in breast cancer?

1 reference

12 December 2020

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell

1 reference

12 December 2020

Synergistic stimulation of airway smooth muscle cell mitogenesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/MSB.2009.19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357636%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357636%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference