Toll-like receptors and adaptor molecules in liver disease: update (Q37174620)

18 August 2017

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title

Toll-like receptors and adaptor molecules in liver disease: update (English)

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18 August 2017

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David A Brenner

2

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author name string

Ekihiro Seki

series ordinal

1

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PubMed ID

18506843

18 August 2017

language of work or name

English

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publication date

1 July 2008

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18 August 2017

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18 August 2017

48

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18 August 2017

322-335

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18 August 2017

1

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Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

18 August 2017

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

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21 January 2018

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MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity

21 January 2018

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Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network.

21 January 2018

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Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.

21 January 2018

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Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice

21 January 2018

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Reduced early alcohol-induced liver injury in CD14-deficient mice

21 January 2018

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TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes.

21 January 2018

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TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection

21 January 2018

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Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells.

21 January 2018

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Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

21 January 2018

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Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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7 January 2021

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

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7 January 2021

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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7 January 2021

Hepatic T cells and liver tolerance

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7 January 2021

Toll-like receptor signaling in the liver

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7 January 2021

Liver: An organ with predominant innate immunity

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7 January 2021

Pattern recognition receptors: a contemporary view on liver diseases.

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7 January 2021

Negative regulation of toll-like receptor-mediated immune responses

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7 January 2021

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

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7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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7 January 2021

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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7 January 2021

Recognition of single-stranded RNA viruses by Toll-like receptor 7

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

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7 January 2021

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

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7 January 2021

TLR4 links innate immunity and fatty acid-induced insulin resistance

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7 January 2021

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

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7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

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7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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7 January 2021

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

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7 January 2021

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

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7 January 2021

MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA

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7 January 2021

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

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7 January 2021

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

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7 January 2021

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

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7 January 2021

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

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7 January 2021

The apoptotic signaling pathway activated by Toll-like receptor-2

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7 January 2021

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

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7 January 2021

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

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7 January 2021

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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7 January 2021

Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta

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7 January 2021

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

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7 January 2021

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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7 January 2021

ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules

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7 January 2021

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

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7 January 2021

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

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7 January 2021

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

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7 January 2021

IRAK-M is a negative regulator of Toll-like receptor signaling

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7 January 2021

SOCS-1 participates in negative regulation of LPS responses

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7 January 2021

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

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7 January 2021

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

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7 January 2021

TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling

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7 January 2021

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

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7 January 2021

PI3K-mediated negative feedback regulation of IL-12 production in DCs

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7 January 2021

SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

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7 January 2021

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

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7 January 2021

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

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7 January 2021

Negative regulation of Toll-like-receptor signaling by IRF-4.

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7 January 2021

IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages

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7 January 2021

Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade

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7 January 2021

Intracellular NOD-like receptors in host defense and disease

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7 January 2021

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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7 January 2021

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

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7 January 2021

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

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7 January 2021

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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7 January 2021

Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice

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7 January 2021

The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage

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7 January 2021

Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice

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7 January 2021

HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells.

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7 January 2021

Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide

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7 January 2021

Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.

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7 January 2021

TLR4 enhances TGF-beta signaling and hepatic fibrosis

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7 January 2021

Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells

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7 January 2021

Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.

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7 January 2021

Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid

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7 January 2021

Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction

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7 January 2021

Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M

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7 January 2021

Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver

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7 January 2021

Kupffer cell inactivation prevents lipopolysaccharide-induced structural changes in the rat liver sinusoid: an electron-microscopic study

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7 January 2021

Type I interferon dependence of plasmacytoid dendritic cell activation and migration.

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7 January 2021

The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses

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7 January 2021

Cytokine-Induced Inflammatory Liver Injuries

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7 January 2021

Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways

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7 January 2021

B cell intrinsic TLR signals amplify but are not required for humoral immunity

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7 January 2021

Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling

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7 January 2021

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation

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7 January 2021

Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.

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7 January 2021

Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice

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7 January 2021

Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury

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7 January 2021

Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance

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7 January 2021

Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages

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7 January 2021

Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis

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7 January 2021

A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells

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7 January 2021

Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection

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7 January 2021

Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice

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7 January 2021

Implication of CpG-ODN and reactive oxygen species in the inhibition of intracellular growth of Salmonella typhimurium in hepatocytes.

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7 January 2021

The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

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7 January 2021

Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease)

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7 January 2021

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

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7 January 2021

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

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7 January 2021

Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice

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7 January 2021

NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease

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7 January 2021

Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver

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7 January 2021

Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP-1 pathway

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7 January 2021

Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts

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7 January 2021

Acute ethanol administration profoundly alters poly I:C-induced cytokine expression in mice by a mechanism that is not dependent on corticosterone

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7 January 2021

Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4.

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7 January 2021

Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis

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7 January 2021

Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis

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7 January 2021

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

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7 January 2021

Non-alcoholic fatty liver disease: lumen–liver interactions and possible role for probiotics

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7 January 2021

Metabolic endotoxemia initiates obesity and insulin resistance

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7 January 2021

Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis

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7 January 2021

Intestinal microflora in patients with liver cirrhosis

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7 January 2021

Bacterial translocation (BT) in cirrhosis

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7 January 2021

The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: results of a double-blind randomized study.

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7 January 2021

Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis

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7 January 2021

LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice.

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7 January 2021

A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C.

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7 January 2021

Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation

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7 January 2021

Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells

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7 January 2021

STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity.

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7 January 2021

Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis

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7 January 2021

Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses

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7 January 2021

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

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7 January 2021

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

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7 January 2021

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

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7 January 2021

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

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7 January 2021

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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7 January 2021

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6

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7 January 2021

Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins

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7 January 2021

Viral and Host Factors Induce Macrophage Activation and Loss of Toll-Like Receptor Tolerance in Chronic HCV Infection

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7 January 2021

Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function

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7 January 2021

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

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7 January 2021

Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus

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7 January 2021

Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes

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7 January 2021

TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).

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7 January 2021

Additive effects of CpG ODN and R-848 as adjuvants on augmenting immune responses to HBsAg vaccination.

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7 January 2021

HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling

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7 January 2021

CXCL10 regulates liver innate immune response against ischemia and reperfusion injury

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7 January 2021

Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion

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7 January 2021

Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury

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7 January 2021

Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model

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7 January 2021

Immune role of hepatic TLR-4 revealed by orthotopic mouse liver transplantation

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7 January 2021

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7 January 2021

Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration

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7 January 2021

Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4

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7 January 2021

Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice

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7 January 2021

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

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7 January 2021

Impaired liver regeneration in mice by lipopolysaccharide via TNF-α/kallikrein–mediated activation of latent TGF-β

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7 January 2021

Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma).

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7 January 2021

Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis

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7 January 2021

Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis

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7 January 2021

Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis

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7 January 2021

Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

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7 January 2021

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis

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7 January 2021

AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers

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7 January 2021

Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis

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7 January 2021

Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis.

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7 January 2021

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

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7 January 2021

Role of toll-like receptors in spontaneous commensal-dependent colitis

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7 January 2021

Identifiers

DOI

10.1002/HEP.22306

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18 August 2017

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PubMed ID

18506843