Relating conformation to function in integrin α5β1. (Q37086651)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27317747%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Relating conformation to function in integrin α5β1 (English)

1 reference

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14 March 2020

5

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14 March 2020

Carlos Cabanas

7

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14 March 2020

author name string

Yang Su

1

1 reference

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14 March 2020

Wei Xia

2

1 reference

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14 March 2020

Jing Li

3

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14 March 2020

Thomas Walz

4

1 reference

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14 March 2020

Dietmar Vestweber

6

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14 March 2020

Chafen Lu

8

1 reference

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14 March 2020

Timothy A Springer

9

1 reference

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14 March 2020

language of work or name

English

0 references

publication date

17 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27317747%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

14 March 2020

published in

1 reference

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14 March 2020

volume

113

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14 March 2020

issue

27

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14 March 2020

page(s)

E3872-81

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β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece

14 March 2020

cites work

1 reference

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Metal ion and ligand binding of integrin α5β1

29 September 2017

1 reference

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An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2

29 September 2017

1 reference

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Complete integrin headpiece opening in eight steps

29 September 2017

1 reference

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EMEN2: an object oriented database and electronic lab notebook

29 September 2017

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α(V)β(3) integrin crystal structures and their functional implications

29 September 2017

1 reference

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The RGD finger of Del-1 is a unique structural feature critical for integrin binding

29 September 2017

1 reference

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Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

29 September 2017

1 reference

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Iterative stable alignment and clustering of 2D transmission electron microscope images

29 September 2017

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Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy

29 September 2017

1 reference

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Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

29 September 2017

1 reference

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Fibronectins, their fibrillogenesis, and in vivo functions

29 September 2017

1 reference

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Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

29 September 2017

1 reference

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Focal adhesions are sites of integrin extension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Structure of an integrin with an αI domain, complement receptor type 4

29 September 2017

1 reference

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Anti-integrin monoclonal antibodies

29 September 2017

1 reference

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Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

29 September 2017

1 reference

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Structural basis of integrin regulation and signaling

29 September 2017

1 reference

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Negative staining and image classification — powerful tools in modern electron microscopy

29 September 2017

1 reference

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Structure of integrin alpha5beta1 in complex with fibronectin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Crystal structure of the extracellular segment of integrin alpha Vbeta3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

29 September 2017

1 reference

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Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

29 September 2017

1 reference

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A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.

29 September 2017

1 reference

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Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization

29 September 2017

1 reference

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Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

29 September 2017

1 reference

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Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

27 June 2018

1 reference

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Are changes in integrin affinity and conformation overemphasized?

27 June 2018

1 reference

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Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies.

27 June 2018

1 reference

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A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

27 June 2018

1 reference

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Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941492

Golgi bypass: skirting around the heart of classical secretion

3 September 2018

1 reference

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The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1605074113

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1605074113

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1605074113

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27317747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27317747

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1605074113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27317747%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27317747%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference