The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy (Q58058153)

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scientific article published in Journal of Biological Chemistry

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English	The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy	scientific article published in Journal of Biological Chemistry

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17 October 2019

The inhibitory anti-beta1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy. Evidence for allosteric inhibition of integrin function (English)

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17 October 2019

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monoclonal antibody

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1

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17 October 2019

Martin J. Humphries

3

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17 October 2019

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S K Akiyama

2

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17 October 2019

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1 August 1996

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17 October 2019

Journal of Biological Chemistry

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17 October 2019

271

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17 October 2019

34

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17 October 2019

20365-20374

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17 October 2019

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Leukocyte integrins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Divalent cation regulation of the function of the leukocyte integrin LFA-1

1 reference

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21 January 2018

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen

1 reference

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21 January 2018

A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.

1 reference

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21 January 2018

Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Fibronectin receptors of mononuclear phagocytes: binding characteristics and biochemical isolation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin alpha 5 beta 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Chemical cross-linking leads to two high molecular mass aggregates of rat alpha 1 beta 1 integrin differing in their conformation but not in their composition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Interaction of haemoglobin with protons, CO2 and 2,3-diphosphoglycerate

1 reference

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21 January 2018

An immunologic approach to the conformational equilibria of polypeptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the beta subunit of VLA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.34.20365

21 January 2018

A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components

1 reference

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21 January 2018

Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin

1 reference

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21 January 2018

Identifiers

10.1074/JBC.271.34.20365

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8702772%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8702772%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

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