Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor (Q27678221)

2

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Emiko Mihara

3

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Terukazu Nogi

4

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Yuji Sugita

5

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Junichi Takagi

Structure of Collagen Receptor Integrin 1I Domain Carrying the Activating Mutation E317A

6

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language of work or name

English

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publication date

2 April 2012

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published in

Journal of Cell Biology

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volume

197

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issue

1

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page(s)

131-40

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cites work

1 reference

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Closed headpiece of integrin IIb 3 and its complex with an IIb 3-specific antagonist that does not induce opening

20 March 2017

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Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

20 March 2017

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Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

20 March 2017

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Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3

20 March 2017

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

20 March 2017

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

20 March 2017

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Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure

20 March 2017

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2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

20 March 2017

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

20 March 2017

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20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Structure validation by Calpha geometry: phi,psi and Cbeta deviation

20 March 2017

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Integrins: bidirectional, allosteric signaling machines

20 March 2017

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20 March 2017

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

22 April 2017

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Comparison of simple potential functions for simulating liquid water

20 March 2017

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Processing of X-ray diffraction data collected in oscillation mode

22 April 2017

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

22 April 2017

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MOLREP: an Automated Program for Molecular Replacement

22 April 2017

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N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function: identification of the minimal N-glycosylation requirement for alpha5beta1.

22 April 2017

1 reference

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Structural basis for ligand recognition by integrins

29 September 2017

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Integrin structures and conformational signaling

29 September 2017

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Type II cadherin ectodomain structures: implications for classical cadherin specificity.

29 September 2017

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Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin

29 September 2017

1 reference

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

29 September 2017

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Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

29 September 2017

1 reference

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Structure of integrin alpha5beta1 in complex with fibronectin

29 September 2017

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29 September 2017

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The evolution of cell adhesion

29 September 2017

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Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis

29 September 2017

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Molecular evolution of integrins: genes encoding integrin beta subunits from a coral and a sponge

29 September 2017

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A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments

29 September 2017

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Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

29 September 2017

1 reference

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Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted alpha-helical domain of the integrin beta 1 subunit.

29 September 2017

1 reference

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Identification of a regulatory region of integrin beta 1 subunit using activating and inhibiting antibodies.

2 June 2018

1 reference

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Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function.

2 June 2018

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N-glycosylation of the beta-propeller domain of the integrin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation

27 November 2018

1 reference

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Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain

27 November 2018

1 reference

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Improved treatment of the protein backbone in empirical force fields.

27 November 2018

1 reference

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Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

Molecular Basis of Ligand Recognition by Integrin α5β1

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317794

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22451694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201111077

1 reference

2778224

2778224

1 reference

1 reference

1 reference