Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma (Q36891677)

16 August 2017

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma (English)

1 reference

16 August 2017

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Alba Luengo

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

10

Tyler Jacks

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

3

Kathryn M Miller

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Talya L Dayton

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Vasilena Gocheva

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

William J Israelsen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Arjun Bhutkar

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Shawn M Davidson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Roderick T Bronson

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Matthew G Vander Heiden

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

publication date

28 April 2016

1 reference

16 August 2017

14

1 reference

inferred from page(s)

published in

Genes & Development

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

1020-1033

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

4 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4863734/fullTextXML

inferred from PubMed Central ID database lookup

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Lack of Evidence for PKM2 Protein Kinase Activity

29 September 2017

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29 September 2017

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29 September 2017

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SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells

29 September 2017

1 reference

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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

29 September 2017

1 reference

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29 September 2017

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29 September 2017

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

29 September 2017

1 reference

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EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis

29 September 2017

1 reference

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Metabolic syndrome and risk of cancer: a systematic review and meta-analysis

29 September 2017

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

29 September 2017

1 reference

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An integrated encyclopedia of DNA elements in the human genome

29 September 2017

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

29 September 2017

1 reference

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

29 September 2017

1 reference

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

29 September 2017

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Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass

29 September 2017

1 reference

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Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace

29 September 2017

1 reference

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

29 September 2017

1 reference

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Choline metabolism in malignant transformation

29 September 2017

1 reference

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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

29 September 2017

1 reference

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Estrogen receptors and the metabolic network

29 September 2017

1 reference

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29 September 2017

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

29 September 2017

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

29 September 2017

1 reference

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29 September 2017

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29 September 2017

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29 September 2017

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

29 September 2017

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

29 September 2017

1 reference

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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

29 September 2017

1 reference

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

29 September 2017

1 reference

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The medical risks of obesity

29 September 2017

1 reference

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

29 September 2017

1 reference

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TopHat: discovering splice junctions with RNA-Seq

29 September 2017

1 reference

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The molecular determinants of de novo nucleotide biosynthesis in cancer cells

29 September 2017

1 reference

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

29 September 2017

1 reference

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

29 September 2017

1 reference

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Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

29 September 2017

1 reference

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Hepatocellular carcinoma pathogenesis: from genes to environment

29 September 2017

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

29 September 2017

1 reference

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Pyruvate kinase type M2 and its role in tumor growth and spreading

29 September 2017

1 reference

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Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

29 September 2017

1 reference

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Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

29 September 2017

1 reference

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Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Alternative splicing of the pyruvate kinase M gene in a minigene system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Interleukin 18 accelerates the hepatic cell proliferation in rat liver regeneration after partial hepatectomy.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4863734

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27125672

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1101/GAD.278549.116

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

release_vwxpif4axvagfesja5zir34gje

4 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vwxpif4axvagfesja5zir34gje

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27125672%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference